Dimethyl Fumarate

Catalog No.S2586

Dimethyl Fumarate Chemical Structure

Molecular Weight(MW): 144.13

Dimethyl fumarate is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis.

Size Price Stock Quantity  
In DMSO USD 140 In stock
USD 97 In stock
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1 Customer Review

  • DMF enhances proteasome inhibitor toxicity in tumor cells. (A) GBM5/6/12/14 cells were treated with DMF (5 μM), velcade (10 nM) or the drug combination. Cells were isolated 24 h after treatment and viability determined by trypan blue exclusion assay (n = 3, +/− SEM) *P < 0.05 greater than DMF alone.

    Cancer Biol Ther, 2014, 15(12):1646-57.. Dimethyl Fumarate purchased from Selleck.

Purity & Quality Control

Biological Activity

Description Dimethyl fumarate is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis.
In vitro

Dimethyl fumarate causes short-lived oxidative stress, which leads to increased levels and nuclear localization of the transcription factor nuclear factor erythroid 2-related factor 2 and a subsequent increase in glutathione synthesis and recycling in neuronal cells. [1] Dimethyl fumarate inhibits dendritic cell (DC) maturation by reducing inflammatory cytokine production (IL-12 and IL-6) and the expression of MHC class II, CD80, and CD86. Dimethyl fumarate impairs nuclear factor κB (NF-κB) signaling via reduced p65 nuclear translocalization and phosphorylation. Dimethyl fumarate inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation by suppression of both NF-κB and ERK1/2-MSK1 signaling. [2] Dimethyl fumarate inhibits TNF-alpha-induced nuclear entry of NF-kappaB in rat heart endothelial cells (RHEC). [3] Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and neurotoxin release. Dimethyl fumarate attenuates CCL2-induced monocyte chemotaxis, suggesting that Dimethyl fumarate could decrease recruitment of activated monocytes to the CNS in response to inflammatory mediators. [4]

In vivo Dimethyl fumarate inhibits nuclear entry of NF-kappaB in RHEC and reduces myocardial infarct size after ischemia and reperfusion in rats in vivo. [3] Dimethyl fumarate oral administration is shown to upregulate mRNA and protein levels of Nrf2 and Nrf2-regulated cytoprotective genes, attenuate 6-OHDA induced striatal oxidative stress and inflammation in C57BL/6 mice. [5]

Protocol

Solubility (25°C)

In vitro DMSO 29 mg/mL (201.2 mM)
Ethanol 10 mg/mL (69.38 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 144.13
Formula

C6H8O4

CAS No. 624-49-7
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02969304 Enrolling by invitation Multiple Sclerosis Biogen December 2016 --
NCT02981082 Recruiting Systemic Sclerosis|Pulmonary; Hypertension University of Pittsburgh|Biogen December 2016 Phase 1
NCT02901106 Not yet recruiting Multiple Sclerosis, Relapsing-Remitting Fondation Ophtalmologique Adolphe de Rothschild December 2016 Phase 4
NCT02959658 Recruiting Primary Progressive Multiple Sclerosis Rigshospitalet, Denmark|Biogen November 2016 Phase 2
NCT02784834 Recruiting Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma Michael Choi|The Leukemia and Lymphoma Society|University of California, San Diego June 2016 Phase 1
NCT01815723 Withdrawn Plaque Psoriasis Forward-Pharma GmbH June 2016 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID