Molecular Weight(MW): 144.13
Dimethyl fumarate (DMF)is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis.
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DMF enhances proteasome inhibitor toxicity in tumor cells. (A) GBM5/6/12/14 cells were treated with DMF (5 μM), velcade (10 nM) or the drug combination. Cells were isolated 24 h after treatment and viability determined by trypan blue exclusion assay (n = 3, +/− SEM) *P < 0.05 greater than DMF alone.
Cancer Biol Ther, 2014, 15(12):1646-57.. Dimethyl Fumarate purchased from Selleck.
Purity & Quality Control
|Description||Dimethyl fumarate (DMF)is the methyl ester of fumaric acid, used to treat people with relapsing forms of multiple sclerosis.|
Dimethyl fumarate causes short-lived oxidative stress, which leads to increased levels and nuclear localization of the transcription factor nuclear factor erythroid 2-related factor 2 and a subsequent increase in glutathione synthesis and recycling in neuronal cells.  Dimethyl fumarate inhibits dendritic cell (DC) maturation by reducing inflammatory cytokine production (IL-12 and IL-6) and the expression of MHC class II, CD80, and CD86. Dimethyl fumarate impairs nuclear factor κB (NF-κB) signaling via reduced p65 nuclear translocalization and phosphorylation. Dimethyl fumarate inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation by suppression of both NF-κB and ERK1/2-MSK1 signaling.  Dimethyl fumarate inhibits TNF-alpha-induced nuclear entry of NF-kappaB in rat heart endothelial cells (RHEC).  Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and neurotoxin release. Dimethyl fumarate attenuates CCL2-induced monocyte chemotaxis, suggesting that Dimethyl fumarate could decrease recruitment of activated monocytes to the CNS in response to inflammatory mediators. 
|In vivo||Dimethyl fumarate inhibits nuclear entry of NF-kappaB in RHEC and reduces myocardial infarct size after ischemia and reperfusion in rats in vivo.  Dimethyl fumarate oral administration is shown to upregulate mRNA and protein levels of Nrf2 and Nrf2-regulated cytoprotective genes, attenuate 6-OHDA induced striatal oxidative stress and inflammation in C57BL/6 mice. |
-  Albrecht P, et al. J Neuroinflammation,?012, 9, 163.
-  Peng H, et al. J Biol Chem,?012, 287(33), 28017-28026.
-  Meili-Butz S, et al. Eur J Pharmacol,?008, 586(1-3), 251-258.
|In vitro||DMSO||29 mg/mL (201.2 mM)|
|Ethanol||10 mg/mL (69.38 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02969304||Enrolling by invitation||Multiple Sclerosis||Biogen||December 2016||--|
|NCT02981082||Recruiting||Systemic Sclerosis|Pulmonary; Hypertension||University of Pittsburgh|Biogen||December 2016||Phase 1|
|NCT02901106||Not yet recruiting||Multiple Sclerosis, Relapsing-Remitting||Fondation Ophtalmologique Adolphe de Rothschild||December 2016||Phase 4|
|NCT02959658||Recruiting||Primary Progressive Multiple Sclerosis||Rigshospitalet, Denmark|Biogen||November 2016||Phase 2|
|NCT02784834||Recruiting||Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma||Michael Choi|The Leukemia and Lymphoma Society|University of California, San Diego||June 2016||Phase 1|
|NCT01815723||Withdrawn||Plaque Psoriasis||Forward-Pharma GmbH||June 2016||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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