Catalog No.S7858 Synonyms: dbcAMP
Molecular Weight(MW): 491.37
Dibutyryl-cAMP (Bucladesine) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP.
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|Description||Dibutyryl-cAMP (Bucladesine) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP.|
Dibutyryl-cAMP inhibits neuronal glucose uptake via PKA activation.  In cultured rat hepatocytes, Dibutyryl-cAMP inhibits inducible nitric oxide synthase expression and NF-kappaB-binding activity.  Dibutyryl-cAMP also suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation. 
|In vivo||In a mouse model, bucladesine (600 nM/mouse, i.p.) reverses zinc chloride- and lead acetate-induced avoidance memory retention impairments. |
|In vitro||DMSO||98 mg/mL warmed (199.44 mM)|
|Water||98 mg/mL warmed (199.44 mM)|
|Ethanol||19 mg/mL warmed (38.66 mM)|
|In vivo||Add solvents individually and in order:
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