Dibutyryl-cAMP (Bucladesine)

Catalog No.S7858 Synonyms: dbcAMP

Dibutyryl-cAMP (Bucladesine) Chemical Structure

Molecular Weight(MW): 491.37

Dibutyryl-cAMP (Bucladesine) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP.

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Biological Activity

Description Dibutyryl-cAMP (Bucladesine) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP.
Targets
PKA [1]
()
In vitro

Dibutyryl-cAMP inhibits neuronal glucose uptake via PKA activation. [1] In cultured rat hepatocytes, Dibutyryl-cAMP inhibits inducible nitric oxide synthase expression and NF-kappaB-binding activity. [2] Dibutyryl-cAMP also suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse RAW264.7 cells NYPHe|BrTnWwY4Tpc44h[XO|YYm= M1HmdVQhcA>? NGjUd4tCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgcY92e2ViUlHXNlY1NjdiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBNWFNvaX7keYNm\CCWTl\hcJBp[SCycn;keYN1cW:wIHHmeIVzKDRiaILzJIJ6KEWOSWPBMEBKSzVyPUK4Mlkh|ryP MX2xNVAxODB{MB?=
mouse S49 cells MVzDfZRwfG:6aXPpeJkh[XO|YYm= M2G0WFUxOCEQvF2= NWKwV3FIOjBvNEmgbC=> NUOxXIVES3m2b4TvfIlkcXS7IHHnZYlve3RiSFfQVnRie2VvZHXmbYNq\W62IH3veZNmKFN2OTDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDheEA2ODBidV2gZYZ1\XJiMkCgeI8hPDliaILzJIJ6KHSrbXWtZ492enOnIIP0eYR6 MXWyNlE3PTh?

... Click to View More Cell Line Experimental Data

In vivo In a mouse model, bucladesine (600 nM/mouse, i.p.) reverses zinc chloride- and lead acetate-induced avoidance memory retention impairments. [4]

Protocol

Animal Research:[4]
+ Expand
  • Animal Models: Mice
  • Formulation: DMSO/water (1:9)
  • Dosages: 600 nM/mouse
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 98 mg/mL warmed (199.44 mM)
Water 98 mg/mL warmed (199.44 mM)
Ethanol 19 mg/mL warmed (38.66 mM)
In vivo Add solvents individually and in order:
10% DMSO+ddH2O
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 491.37
Formula

C18H23N5NaO8P

CAS No. 16980-89-5
Storage powder
in solvent
Synonyms dbcAMP

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID