Compstatin

Catalog No.S8522

Compstatin Chemical Structure

Molecular Weight(MW): 1550.77

Compstatin binds to complement component C3 and inhibits complement activation with IC50 of 12 μM.

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Biological Activity

Description Compstatin binds to complement component C3 and inhibits complement activation with IC50 of 12 μM.
Targets
complement component C3 [4]
12 μM
In vitro

Compstatin binds to native C3 and inhibits its cleavage by C3 convertase. Binding of Compstatin to native C3 is a multistep reaction that is preferred over its binding to the C3 fragments C3b and C3c. N-acetylation of Compstatin provides stability against enzymatic degradation[1]. Compstatin features a high selectivity for human and primate C3. While binding to C3 from baboons and other primates shows comparable interaction profiles as its human counterpart, no binding is detected for C3 from lower mammalian species such as mice, rats, guinea pigs, rabbits, or pigs[3].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
RPE cells NXLnfIRPTnWwY4Tpc44h[XO|YYm= NYLTXYhWPTBidV2= MnPQTY5pcWKrdHnvckBw\iClb33wcIVu\W62IHHjeIl3[XSrb36gbY4hcHWvYX6g[oV1[WxiUmDFJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiCFNXKtPUBnd3KvYYTpc44h[XRiNUCgeW0h[nliZnz1c5Jme2OnbnPlJIF{e2G7IHnuJJBz\XOnbnPlJI9nKGOxbYDs[Y1mdnRvY3;tdIV1[W62IHj1cYFvKHOncoXt M1PKRlI2PDl2MESw

... Click to View More Cell Line Experimental Data

In vivo Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures. Compstatin is a safe and effective complement inhibitor that has the potential to prevent complement activation during and after clinical cardiac surgery. Furthermore, Compstatin can serve as the prototype for designing an orally administrated drug. In the extracorporeal circulation model, Compstatin inhibits the generation of C3a and C5a, the formation of the membrane attack complex, and CD11b expression on neutrophils (PMNs). The peptide also inhibits binding of C3/C3 fragments, PMNs, and monocytes to the polymer surface[2].

Protocol

Animal Research:

[2]

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  • Animal Models: Juvenile baboons (P. anubis)
  • Formulation: PBS
  • Dosages: 17, 21, 34, 38.5, 50, 63.5 mg/kg
  • Administration: by bolus injection, infusion, or both
    (Only for Reference)

Solubility (25°C)

In vitro Water 100 mg/mL (64.48 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1550.77
Formula

C66H99N23O17S2

CAS No. 206645-99-0
Storage powder
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID