Home Microbiology Fungal inhibitor Climbazole For research use only.

Climbazole

Synonyms: BAY-e 6975

Climbazole(BAY-e 6975) is a broad-spectrum imidazole antifungal agent that can provide anti-dandruff benefits.

Climbazole Chemical Structure

Climbazole Chemical Structure

CAS: 38083-17-9

Selleck's Climbazole has been cited by 1 publication

Purity & Quality Control

Batch: S417801 DMSO] 59 mg/mL] false] Ethanol] 59 mg/mL] false] Water] Insoluble] false Purity: 99.63%
99.63

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Biological Activity

Description Climbazole(BAY-e 6975) is a broad-spectrum imidazole antifungal agent that can provide anti-dandruff benefits.
In vitro
In vitro

Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role in the pathogenesis of dandruff. Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole. For climbazole, the range of MICs is between < 0.06 and 1 μg/mL with an empirical median of 0.06 μg/mL. [1]
In Vivo
In vivo

Climbazole is not mutagenic in the Salmonella typhimurium or Escherichia coli Ames assay and does not induce micronuclei in human lymphocytes. An in vivo mouse micronucleus test also shows it is non-mutagenic up to a maximum tolerated dose (MTD) of 150 mg/kg administered orally. In the in vivo/in vitro unscheduled DNA synthesis assay, climbazole shows no evidence of DNA damage in the livers of rats at doses up to the MTD of 200 mg/kg orally. A toxicokinetic study is performed in mice with oral administration of [14C]-climbazole (150 mg/kg). Radioactivity (20.42 μg-equiv./g plasma) is detected 15 min after oral administration of [14C]-climbazole, and the peak concentration is 62.96 μg-equiv./g plasma at 8 h after dosing. [2]

Chemical Information & Solubility

Molecular Weight 292.76 Formula

C15H17ClN2O2
CAS No. 38083-17-9 SDF Download Climbazole SDF
Smiles CC(C)(C)C(=O)C(N1C=CN=C1)OC2=CC=C(C=C2)Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 59 mg/mL ( (201.53 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 59 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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