Cinepazide maleate
Catalog No.S3045
Molecular Weight(MW): 533.57
Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.
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Biological Activity
| Description | Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator. | |
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| In vivo | Cinepazide (3 mg/kg -30 mg/kg, i.v.) produces a dose-related and transient increase in vertebral, carotid, renal and femoral arterial flow as well as cardiac output and a decrease in total peripheral resistance in anesthetized dogs. Cinepazide exerts positive inotropic and chronotropic actions. Cinepazide (30 mg/kg, i.v.) potentiates the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP. Intravertebral cinepazide (1 mg -10 mg) increases vertebral blood flow in a dose-related manner and the effect is partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. [1] Cinepazide is well absorbed and more than 60% of the dose is excreted within 24 hours. In 5 days, rats, dogs, and man excretes in the urine and faeces respectively 36.7% and 58.3%, 33.4% and 68.6%, and 61.3% and 38.1% dose. [2] Cinepazide at doses of 1 mg/kg - 3 mg/kg i.v. decreases systemic blood pressure by 4% and reflexly increases heart rate by 8%. [3] Cinepazide selectively stimulates the functional activities of 5-HT neurons in the brain, which are depressed by hypoxia. [4] |
Protocol
| Animal Research:[4] |
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Solubility (25°C)
| In vitro | DMSO | 107 mg/mL (200.53 mM) |
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| Water | 107 mg/mL (200.53 mM) | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 533.57 |
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| Formula | C22H31N3O5.C4H4O4 |
| CAS No. | 26328-04-1 |
| Storage | powder |
| Synonyms | N/A |
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Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT01851759 | Unknown status | Ischemic Stroke | Xijing Hospital | October 2013 | Phase 2 |
| NCT01831011 | Completed | Acute Ischemic Stroke | Xijing Hospital | July 2008 | Phase 2 |
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