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Fisogatinib (BLU-554)

Name: Fisogatinib (BLU-554)
Brand: Selleck Chemicals
SKU: S8503
Rating: 5 (7 reviews)

Catalog No.S8503 Purity: 99.91%

Fisogatinib (BLU-554) is a potent, highly-selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50s for FGFR1-3 is 624-2203 nM.

Fisogatinib (BLU-554) Chemical Structure

CAS: 1707289-21-1

Selleck's Fisogatinib (BLU-554) has been cited by 7 publications

Purity & Quality Control

Batch: Purity: 99.91%

99.91

Fisogatinib (BLU-554) Related Products

Related Targets	FGFR1 FGFR2 FGFR3 FGFR4	Click to Expand
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Signaling Pathway

FGFR Signaling Pathway

Choose Selective FGFR Inhibitors

Biological Activity

Description

Fisogatinib (BLU-554) is a potent, highly-selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50s for FGFR1-3 is 624-2203 nM.

Targets

FGFR4 ^[1]
(Cell-free assay)

5 nM

In vitro
In vitro	BLU-554 exploits a unique interaction with FGFR4 to confer potency and selectivity
Cell Research	Cell lines	ST8814 resistant cells
	Concentrations	1 µM
	Incubation Time	4 h
	Method	ST8814 resistant cells were treated with DMSO or BLU-554 at 1 µM for 4 hrs.

In Vivo
In vivo	BLU-554 is well tolerated in these tumor models. Administration of BLU-554 induces tumor regression in liver cancer models^[1].
Animal Research	Animal Models	Male FVB/NRj mice
	Dosages	10 mg/kg
	Administration	p.o.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT02508467	Active not recruiting	Hepatocellular Carcinoma (HCC)	Blueprint Medicines Corporation	July 31 2015	Phase 1

References

Chemical Information & Solubility

Molecular Weight	503.38	Formula	C₂₄H₂₄Cl₂N₄O₄
CAS No.	1707289-21-1	SDF	Download Fisogatinib (BLU-554) SDF
Smiles	COC1=CC(=C(C(=C1Cl)C2=CC3=CN=C(N=C3C=C2)NC4COCCC4NC(=O)C=C)Cl)OC
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (198.65 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

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