Azelaic acid

Synonyms: Nonanedioic acid, Finacea, Azelex, Anchoic acid

Azelaic acid (Nonanedioic acid, Finacea, Azelex, Anchoic acid) is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.

Azelaic acid Chemical Structure

Azelaic acid Chemical Structure

CAS: 123-99-9

Purity & Quality Control

Batch: S455001 DMSO] 37 mg/mL] false] Water] 37 mg/mL] false] Ethanol] 37 mg/mL] false Purity: >97%
97

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Biological Activity

Description Azelaic acid (Nonanedioic acid, Finacea, Azelex, Anchoic acid) is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.
In vitro
In vitro AZ(Azelaic acid) combined with taurine (Tau) show more inhibitory effects in melanocytes than the treatment of AZ alone. AZ combined with Tau inhibits the melanin production and tyrosinase activity of B16F10 melanoma cells without significant cytotoxicity. Also inhibitory effects after treatment with these combined chemical are stronger than AZ alone on melanogenesis[2].
Cell Research Cell lines The mouse melanoma cell line B16F10
Concentrations 20 mM
Incubation Time 24 h
Method

B16F10 melanoma cells are seeded at a density of 2.5×105 cells/60 mm culture dish. The cells are treated with Azelaic acid combined with Tau for 24 hr. The cells pellets are dissolved in 1 N NaOH at 60°C for 1 hr. The relative melanin content is determined by measuring the absorbance at 475 nm in ELISA reader.

In Vivo
In vivo Azelaic acid exhibits an anti-atherogenic effect. Its athero-protective effect is not related to changes in plasma lipid content. Azelaic acid supplementation decreases the level of CD68 macrophage marker by 34% (p<0.05)[1].
Animal Research Animal Models Low density lipoprotein receptor knockout (LDLr−/−) mice
Dosages 0.50%
Administration oral administration

Chemical Information & Solubility

Molecular Weight 188.22 Formula

C9H16O4

CAS No. 123-99-9 SDF Download Azelaic acid SDF
Smiles C(CCCC(=O)O)CCCC(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 37 mg/mL ( (196.57 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 37 mg/mL

Ethanol : 37 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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