Amoxicillin

Synonyms: Amoxycillin

Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms.

Amoxicillin Chemical Structure

Amoxicillin Chemical Structure

CAS: 26787-78-0

Selleck's Amoxicillin has been cited by 5 publications

Purity & Quality Control

Batch: Purity: 99.69%
99.69

Amoxicillin Related Products

Choose Selective Bacterial Inhibitors

Biological Activity

Description Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms.
In vitro
In vitro Amoxicillin treated cells secrete high amounts of interleukin-5 and mostly lower or no amounts of tumor necrosis factor alpha, interleukin-4, and interferon-gamma. Amoxicillin-specific T cell clones fails to show drug-specific cytotoxicity, but killed target cells in the presence of concanavalin A, indicating a principal ability to be cytolytic. [1] Amoxicillin releases faster in pH 1.0 hydrochloric acid (HCl) than in pH 7.8 phosphate buffer. Amoxicillin would be degraded to some extent in a pH 1.0 HCl medium at 37 degrees C, which indicated that amoxicillin is not stable in an acidic surrounding. [2] Amoxicillin inhibits 4 of 15 isolates at 8 mg/mL or less but is not bactericidal against any of the isolates at that concentration. Amoxicillin in combination with clavulanic acid is bactericidal for 14 of 15 isolates tested at an amoxicillin concentration of 4 mg/mL or less and a clavulanic acid concentration of 2 mg/mL or less. [3] Amoxicillin inhibits 50% of isolates tested decreased from 0.5 mg/mL (range, 0.25 to 1 mg/mL) to 0.06 mg/mL (range, 0.01 to 0.25 mg/mL) in the presence of only 4 mg of cefotaxime per mL. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05464615 Not yet recruiting
Penicillin Allergy
Geisinger Clinic
January 15 2024 Early Phase 1
NCT04408508 Not yet recruiting
Penicillin Allergy
Saskatchewan Health Authority - Regina Area
December 2023 Not Applicable
NCT05309928 Recruiting
Pregnancy Related
University of Alabama at Birmingham
August 29 2023 Phase 1
NCT05340257 Not yet recruiting
Infections Bacterial
GlaxoSmithKline
June 23 2023 Phase 2

Chemical Information & Solubility

Molecular Weight 365.4 Formula

C16H19N3O5S

CAS No. 26787-78-0 SDF Download Amoxicillin SDF
Smiles CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 73 mg/mL ( (199.78 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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