Alcaftadine

Catalog No.S4625 Synonyms: Lastacaft, R89674

Alcaftadine Chemical Structure

Molecular Weight(MW): 307.39

Alcaftadine is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. Alcaftadine is also an antagonist for H2 and H4 receptors with no affinity for the H3 receptor.

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Biological Activity

Description Alcaftadine is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. Alcaftadine is also an antagonist for H2 and H4 receptors with no affinity for the H3 receptor.
Targets
H1 receptor [1]
(Cell-free assay)
H2 receptor [1]
(Cell-free assay)
H4 receptor [1]
(Cell-free assay)
8.5(pKi) 7.2(pKi) 5.8(pKi)

Protocol

Solubility (25°C)

In vitro Ethanol 61 mg/mL (198.44 mM)
DMSO 28 mg/mL (91.08 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 307.39
Formula

C19H21N3O

CAS No. 147084-10-4
Storage powder
Synonyms Lastacaft, R89674

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID