Torsemide

Catalog No.S1698 Synonyms: AC-4464, JDL-464

Torsemide  Chemical Structure

Molecular Weight(MW): 348.42

Torsemide is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.

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Biological Activity

Description Torsemide is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.
Targets
Cl- channel [1]
In vitro

Torsemide inhibits aldosterone secretion by adrenal cells from rats, cows, and guinea pigs stimulated in vitro by potassium, angiotensin, dibutyryl cyclic AMP, ACTH, or corticosterone. [1] Torsemide's primary site of action is the thick ascending loop of Henle in the nephron, where it promotes excretion of sodium, water, and chloride via interaction with the Na+, K+, 2Cl− cotransporter. Torsemide interferes with the secretion of, and receptor ligand binding of, the mineralocorticoid aldosterone in a dose-dependent manner. [2]

In vivo Torsemide results in elevated levels of circulating angiotensin II and aldosterone (supportive of interference with aldosterone at the receptor level) in dogs with experimental mitral regurgitation whereas furosemide results in elevated levels of angiotensin II, only. [2] Torsemide increases the BUN and plasma creatinine concentrations in rats, compared with the baseline value. Torsemide immediately increases urine volume significantly. [3]

Protocol

Solubility (25°C)

In vitro DMSO 3 mg/mL warmed (8.61 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 348.42
Formula

C16H20N4O3S

CAS No. 56211-40-6
Storage powder
Synonyms AC-4464, JDL-464

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02813551 Recruiting Preeclampsia The University of Texas Health Science Center, Houston August 2016 Phase 2
NCT01558674 Terminated Renal Impairment|Heart Failure Merck Sharp & Dohme Corp. May 2014 Phase 1
NCT01788254 Completed Genotype-related Drug Metabolism Matthias Schwab|University Hospital Tuebingen January 2012 Phase 1
NCT01457053 Terminated Acute Decompensated Heart Failure University of Cincinnati November 2011 --
NCT01845194 Completed Drug Biotransformation|Membrane Transport Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH December 2009 Phase 1
NCT00602615 Completed Edema Roxane Laboratories September 2003 --

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