Catalog No.S1698 Synonyms: AC-4464, JDL-464
Molecular Weight(MW): 348.42
Torsemide is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.
Purity & Quality Control
|Description||Torsemide is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.|
Torsemide inhibits aldosterone secretion by adrenal cells from rats, cows, and guinea pigs stimulated in vitro by potassium, angiotensin, dibutyryl cyclic AMP, ACTH, or corticosterone.  Torsemide's primary site of action is the thick ascending loop of Henle in the nephron, where it promotes excretion of sodium, water, and chloride via interaction with the Na+, K+, 2Cl− cotransporter. Torsemide interferes with the secretion of, and receptor ligand binding of, the mineralocorticoid aldosterone in a dose-dependent manner. 
|In vivo||Torsemide results in elevated levels of circulating angiotensin II and aldosterone (supportive of interference with aldosterone at the receptor level) in dogs with experimental mitral regurgitation whereas furosemide results in elevated levels of angiotensin II, only.  Torsemide increases the BUN and plasma creatinine concentrations in rats, compared with the baseline value. Torsemide immediately increases urine volume significantly. |
|In vitro||DMSO||3 mg/mL warmed (8.61 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02813551||Recruiting||Preeclampsia||The University of Texas Health Science Center, Houston||August 2016||Phase 2|
|NCT01558674||Terminated||Renal Impairment|Heart Failure||Merck Sharp & Dohme Corp.||May 2014||Phase 1|
|NCT01788254||Completed||Genotype-related Drug Metabolism||Matthias Schwab|University Hospital Tuebingen||January 2012||Phase 1|
|NCT01457053||Terminated||Acute Decompensated Heart Failure||University of Cincinnati||November 2011||--|
|NCT01845194||Completed||Drug Biotransformation|Membrane Transport||Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH||December 2009||Phase 1|
|NCT00602615||Completed||Edema||Roxane Laboratories||September 2003||--|
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