Ribavirin

Catalog No.S2504 Synonyms: NSC-163039, ICN-1229 ,RTCA, Tribavirin

Ribavirin  Chemical Structure

Molecular Weight(MW): 244.20864

Ribavirin, a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 120 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

3 Customer Reviews

  • (E) Left panel, Western blot showed that 20 μM Ribavirin effectively inhibits elevated Sox2 expression in irradiated SW1990 cells. Right panel, qPCR analysis showed that Sox2 mRNA level in irradiated SW1990 cells at 48 hours was lower than that in non-irradiated SW1990 cells, *p < 0.05. (F) Left panel, Western blot showed 20 μM Ribavirin inhibits elevated Sox2 expression in irradiated BxPc-3 cells. Right panel, qPCR analysis showed that there is no significant fluctuation of Sox2 mRNA in irradiated BxPc-3 cells and Ribavirin did not influence sox2 mRNA level in irradiated BxPc-3 cells.

    Cancer Lett, 2016, 375(1):31-8. . Ribavirin purchased from Selleck.

    Inhibition of viral replication and ensuing myocardial apoptosis ameliorates HDACI-exacerbated viral myocarditis. (A) CVB3-infected cardiac myocytes (MOI, 5) were treated with 1 μM SAHA and the indicated concentrations of ribavirin for 24 h. Cell extracts were analyzed by Western blotting with the indicated antibodies. (B) CVB3-infected cardiac myocytes (MOI, 5) were treated with 1 μM SAHA and 200 μg/ml ribavirin for 24 h. CVB3 titers in cell culture supernatants were determined by TCID50 assay (n = 4). (C) Cardiac myocytes were treated with 200 μg/ml ribavirin for 24 h. Cells morphology was examined by light microscope (scale bar, 100 μm). (D to F) CVB3-infected cardiac myocytes (MOI, 5) were treated with 2 μM SAHA in the presence or absence of 800 μg/ml ribavirin for 24 h. (D) Cell morphology was examined by light microscope (scale bar, 100 μm). (E and F) Cells were collected and stained with 7-AAD and FITC-labeled annexin V, followed by flow cytometric analysis (n = 3). (G and H) BALB/c mice were infected with CVB3 on day 0 and then simultaneously treated with SAHA (50 mg/kg) and ribavirin (100 mg/kg) or vehicle PBS daily from day 0 to day 7 p.i. (G) Survival rate was monitored daily until day 7 p.i. (n = 10). (H) Paraffin sections of heart tissues were prepared on day 7 p.i., and cardiac injury was revealed by H&E (scale bar, 50 μm). *, P < 0.05; ***, P < 0.001.

    J Virol, 2015, 89(20):10512-23.. Ribavirin purchased from Selleck.

  • Establishment of Vero-rBoDV-1-Gluc cells to monitor BoDV-1 replication. (A) Dose- and time-dependent inhibitory effects of ribavirin on BoDV-1 replication. Vero-rBoDV-1-Gluc cells were treated with 20 or 40 μM of ribavirin for the indicated periods, and the luciferase activity in the cell supernatant was measured. (B) Quantification of BoDV-1 RNAs in Vero-rBoDV-1-Gluc cells treated with 20 or 40 μM of ribavirin for 72 h. Values are expressed as the mean + S.E. from 3 biological replicates. *, p < 0.05; **, p < 0.01; ****, p < 0.001.

    Antiviral Res, 2017, 143:237-245. Ribavirin purchased from Selleck.

Purity & Quality Control

Choose Selective Antifection Inhibitors

Biological Activity

Description Ribavirin, a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.
In vitro

Ribavirin significantly reduces the efficiency with which progeny subgenomic replicons transfect new cells in the replicon system, although ribavirin has little effect on levels of HCV replication. Ribavirin increases the mutation frequency of HCV, with the highest rates of mutations being found in the NS5A-encoding region. Ribavirin enhances TH1 while inhibiting T 2 cytokine production by stimulated T cells. [1] Ribavirin shows antiviral activity against a variety of RNA viruses and is used in combination with interferon-alpha to treat hepatitis C virus infection. Ribavirin reduces infectious poliovirus production to as little as 0. 00001% in cell culture. [2] Ribavirin's antiviral activity is exerted directly through lethal mutagenesis of the viral genetic material. [3] Ribavirin markedly reduces viral-induced parameters of macrophage activation at physiologic concentrations (up to 500 mg/mL). Ribavirin inhibits the production of IL-4 by Th2 cells, whereas it does not diminish the production of IFN-gamma in Th1 cells. [4] Ribavirin exhibits antiviral activity against a broad range of both DNA and RNA viruses in vitro. Ribavirin is a cytostatic agent and causes a reduction in synthesis of DNA, RNA and proteins in exposed cells. Ribavirin is thought to induce a switch in T-helper cell phenotype from type 2 to type 1. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
E6SM cell lines MV3GeY5kfGmxbjDhd5NigQ>? NVPKcZFGTW[oZXP0bZZmKGOxbnPlcpRz[XSrb36gdoVyfWm{ZXSgeI8hcW6qaXLpeEBJ\XKyZYOgd4lueGyneDD2bZJ2ey1zKFjTWk0yMSBxIITofY1qdmVia3nuZZNmKGSnZnnjbYVvfCBqVFutLWIzODB4ID:gWm1YOTh|NzDpcoR2[2WmIHP5eI9x[XSqaXPpeJkh[nliNUClJIlvKEV4U12gZ4VtdCCuaX7ld{whTUN3ME2wMlAxPSEQvF2= MmjNNVE1QTV3OE[=
MDCK cells NUnSPXRnTnWwY4Tpc44h[XO|YYm= Mn7yN{Bl[Xm| MWnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDJcoZtfWWwenGgRkB3cXK3czCoRk9JUy93L{eyLUBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJJZqenW|LXnu[JVk\WRiY4n0c5BifGirYzDl[oZm[3RiYX\0[ZIhOyCmYYnzJIJ6KG2rY4Lvd4NweGmlIHHuZYx6e2m|LDDFR|UxRTBwMEm0JO69VQ>? M2jxU|I{OTF5MUez
mouse L1210 cells M37LTGZ2dmO2aX;uJIF{e2G7 NH:2N40zOC14MDDtbY5{ M{fXVmlvcGmkaYTpc44hd2ZiSV3QSGghcW5ibX;1d4UhVDF{MUCgZ4VtdHNiYYPz[ZN{\WRiYYOg[o9zdWG2aX;uJI9nKFt{LEitN2hecHmyb4jhcpRpcW6nIH\yc40hYzJuOD2zTH1KVVBiYX\0[ZIhOjBidH:gOlAhdWmwczygTWM2OD1zIN88US=> M3vzT|IzPTV3MUWy
human CEM cells MYHGeY5kfGmxbjDhd5NigQ>? MornNlAuPjBibXnudy=> NF7sNGJKdmirYnn0bY9vKG:oIFnNVGRJKGmwIHj1cYFvKEOHTTDj[YxteyCjc4Pld5Nm\CCjczDmc5Ju[XSrb36gc4YhYzJuOD2zTH1pgXCxeHHueIhqdmViZoLvcUBcOix6LUPIYWlOWCCjZoTldkAzOCC2bzC2NEBucW6|LDDJR|UxRTFizszN M3zETFIzPTV3MUWy
BHK21 cell line NI[zSJdHfW6ldHnvckBie3OjeR?= M4f3fGlvcGmkaYTpc44hd2ZiV3XzeEBPcWynII\pdpV{KF[OUDDy[ZBtcWOxbjDpckBDUEt{MTDj[YxtKGyrbnWsJGVEPTB;MT6xJO69VQ>? MYOxOlU{QTRyMh?=
HeLa cell MnnnSpVv[3Srb36gZZN{[Xl? NGrvNXFG\m[nY4TpeoUh[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JJJme3CrcnH0c5J6KHO7bnHweIlidCiUU2[pJJZqenW|LXnu[JVk\WRiY4n0c5BifGirY3n0fUBjgSB3MDWgbY4hUGWOYTDj[YxtKGyrbnXzMEBGSzVyPUGuOUDPxE1? NWDzV4ZJOTF2OUW1PFY>
MDCK cells M{TmcWZ2dmO2aX;uJIF{e2G7 NGf1OHE{PiCq NIT0PHRCdnSraX7mcJVmdnqjIHHjeIl3cXS7IHHnZYlve3RiaX7mcJVmdnqjIFGgeolzfXNiSEHONUBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bIlkKGWoZnXjeEBi\nSncjCzOkBpenNuIFnDOVA:OS57IN88US=> MkTINlI{PDF7NEO=
MDBK cells MVPGeY5kfGmxbjDhd5NigQ>? NIjv[ngzKGSjeYO= M2fU[mFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGJwfmmwZTD2bZJidCCmaXHydohm[SC4aYL1d{AyNU6DRFygRXRESyCYUkWzOEBqdm[nY4Tl[EBqdiCPRFLLJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iC4aYLhcEBkgXSxcHH0bIlkKGWoZnXjeEBi\nSncjCyJIRigXNiYoSgUXRUKGG|c3H5MEBGSzVyPUSuOkDPxE1? M4XySVIzQTR2M{Oz
african green monkey Vero cells NV[3boRkTnWwY4Tpc44h[XO|YYm= NXXKeGY5PSCmYYnz NEXXOo1CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBTW1ZiQUKgbY5n\WO2ZXSgbY4h[W[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDh[pRmeiB3IHThfZMh[nlicHzhdZVmKHKnZIXjeIlwdiCjc4PhfUwhTUN3ME23JO69VQ>? NWf1Sm9jOjB|NUm4PVg>
HEL cells NGjPbHVHfW6ldHnvckBie3OjeR?= MUCyMVMh\GG7cx?= NEPTOHFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJ\XKyZYOgd4lueGyneDD2bZJ2eyBzIFvPV{Bqdm[nY4Tl[EBqdiCKRVygZ4VtdHNiYYPz[ZN{\WRiYYOgdJJwfGWldHnvckBnem:vII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[W[2ZYKgNkB1dyB|IHThfZMh[nliTWTUJIF{e2G7LDDFR|UxRTFyIN88US=> M4WyblIxODN2N{Gx
HEK293 cells M3H5fmZ2dmO2aX;uJIF{e2G7 NIO3dJgzPCCq MVTJcohq[mm2aX;uJI9nKGmwZnz1[Y57[SCDII\pdpV{KFKQQT3k[ZBmdmSnboSgVm5CKHCxbInt[ZJie2ViZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjZoTldkAzPCCqcoOgZpkh\HWjbDDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NVUh|ryP NILxNlkzPDNzM{ezNC=>
human BE(2)-C cells NX\lW5RLTnWwY4Tpc44h[XO|YYm= MYGxPE0zOCCq M2myTGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JHdme3Sncn6g[ZF2cW6nIHXuZ4VxcGGub335[YxqfGm|II\pdpV{KGmwZnXjeIVlKGmwIHj1cYFvKEKHKEKpMWMh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCCUTlGgdoVxdGmlYYTpc44h[W[2ZYKgNVghfG9iMkCgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME2xOkDPxE1? MmTKNlQyPTF7NUS=
human HuH7-J20 cells Mon3SpVv[3Srb36gZZN{[Xl? NVrhTG5OSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUEOYIFrGTFEhcW6oZXP0[YQhcW5iaIXtZY4hUHWKNz3KNlAh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCCuaX\lJIN6[2ynIHL5JI1m[XO3cnnu[{B{\WO{ZYTl[EBidGujbHnu[UBxcG:|cHjheIF{\SCuZY\lcEBxemWrbnP1ZoF1\WRid3n0bEBk\WyuczDmc5IhOSCqcjDmc4xtd3enZDDifUB3cXKjbDDpco9kfWyjdHnvckBnd3JiMzDodpMhdWWjc4Xy[YQh[XRiN{KgbJJ{NCCHQ{WwQVMxNjRizszN MYKyOlQzQDh5MB?=
human MT4 cells MkfSR5l1d3SxeHnjxsBie3OjeR?= MX:5OkBp MmfrR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUXQ1KGOnbHzzJIFnfGW{IEm2JIhzeyCkeTDNWHQh[XO|YYmsJGNEPTB;M{Gg{txO M2XPVFE6PDh{NEix
human HuH7 cells NGXKfXJEgXSxdH;4bYPDqGG|c3H5 Mlv1N{Bl[Xm| NHXKXplEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfUh5IHPlcIx{KGmwZnXjeIVlKHerdHigTGNXOWJiYX\0[ZIhOyCmYYnzJIJ6KE2WUzDhd5NigSxiQ1O1NF0{OiEQvF2= M2LYNFIzOTByMkW2
human KB cells NY\6bZpHTnWwY4Tpc44h[XO|YYm= MnnlO|IhcA>? Mn7FRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgVohqdm:4aYL1d{B1gXCnIEGzJIlv\mWldHXkJIlvKGi3bXHuJGtDKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA4OiCqcoOgdoVt[XSrdnWgeI8h[2:wdILvcC=> MoiwO|IzPzNy
human KB cells NGrqUWFHfW6ldHnvckBie3OjeR?= Ml3mNU0yODByIN88[{9udA>? NGHqN5Q4OiCq MXvBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDSbIlvd3[rcoXzJJR6eGViMUOgbY5n\WO2ZXSgbY4hcHWvYX6gT2Ih[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpcWNiZX\m[YN1KGG2IEGgeI8hOTByMDD1[{9udCCjZoTldkA4OiCqcoO= M3\nNlIyOTJ|NB?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 49 mg/mL (200.64 mM)
Water 49 mg/mL (200.64 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 244.20864
Formula

C8H12N4O5

CAS No. 36791-04-5
Storage powder
Synonyms NSC-163039, ICN-1229 ,RTCA, Tribavirin

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01463956 Completed HCV Infection|Liver Cirrhosis, Experimental French National Agency for Research on AIDS and Viral Hepatitis|Merck Sharp & Dohme Corp.|French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS) January 6, 2012 Phase 2
NCT02946034 Not yet recruiting Chronic Kidney Disease|Chronic Hepatitis C Massachusetts General Hospital|AbbVie December 2016 --
NCT02985281 Enrolling by invitation Pharmacological Action National Liver Institute, Egypt|Pharco Pharmaceuticals December 2016 Phase 2|Phase 3
NCT02950870 Not yet recruiting Chronic Hepatitis, C Virus University of Modena and Reggio Emilia December 2016 Phase 4
NCT02992457 Recruiting Hepatitis C Tanta University December 2016 Phase 4
NCT02956629 Recruiting Hepatitis C Merck Sharp & Dohme Corp. November 2016 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field
Tags: buy Ribavirin | Ribavirin ic50 | Ribavirin price | Ribavirin cost | Ribavirin solubility dmso | Ribavirin purchase | Ribavirin manufacturer | Ribavirin research buy | Ribavirin order | Ribavirin mouse | Ribavirin chemical structure | Ribavirin mw | Ribavirin molecular weight | Ribavirin datasheet | Ribavirin supplier | Ribavirin in vitro | Ribavirin cell line | Ribavirin concentration | Ribavirin nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID