Neomycin sulfate

Synonyms: Framycin sulfate

Neomycin sulfate(Framycin sulfate) is an aminoglycoside antibiotic, used to treat bacteria infections.

Neomycin sulfate Chemical Structure

Neomycin sulfate Chemical Structure

CAS: 28002-70-2 ,1405-10-3

Selleck's Neomycin sulfate has been cited by 1 publication

Purity & Quality Control

Batch: Purity: >97%
97

Neomycin sulfate Related Products

Choose Selective Antineoplastic and Immunosuppressive Antibiotics Inhibitors

Biological Activity

Description Neomycin sulfate(Framycin sulfate) is an aminoglycoside antibiotic, used to treat bacteria infections.
In vitro
In vitro

Neomycin interacts preferentially with the ribozyme-substrate complex and that this interaction leads to a reduction in the cleavage rate by stabilizing the ground state of the complex and destabilizing the transition state of the cleavage step. [1] Neomycin effects a conformational change in the structure of trans-activating region (TAR) that can be detected by circular dichroism spectroscopy. Neomycin acts as a noncompetitive inhibitor that can bind to the Tat-TAR complex and increase the rate constant (koff) for dissociation of the peptide from the RNA. [2] Neomycin is the most effective aminoglycoside (groove binder) in stabilizing a DNA triple helix. Neomycin stabilizes TAT, as well as mixed base DNA triplexes, better than known DNA minor groove binders (which usually destabilize the triplex) and polyamines. Neomycin shows a preference for stabilization of TAT triplets but can also accommodate CGC(+) triplets. [3] Neomycin induces a concentration- and voltage-dependent partial block from both the cytosolic and luminal faces of the channel. Neomycin has a greater affinity for the luminal site of interaction than the cytosolic site: zero-voltage dissociation constants (Kb(0)) are respectively 210.20 nM and 589.70 nM for luminal and cytosolic block. Neomycin also exhibits voltage-dependent relief of block at holding potentials >+60 mV. [4]

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05593601 Recruiting
Colonization Asymptomatic
Mahidol University
November 24 2022 Phase 4
NCT00795951 Completed
Dermatitis Contact
Allerderm
November 2008 Phase 4
NCT00058617 Completed
Epstein-Barr Virus-Related Hodgkin Lymphoma|Epstein-Barr Virus-Related Non-Hodgkin Lymphoma|EBV Positive Plasma Cell Neoplasm
Baylor College of Medicine|The Methodist Hospital Research Institute|Center for Cell and Gene Therapy Baylor College of Medicine
January 1996 Phase 1

Chemical Information & Solubility

Molecular Weight 712.72 Formula

C23H46N6O13.H2SO4

CAS No. 28002-70-2 ,1405-10-3 SDF Download Neomycin sulfate SDF
Smiles C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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