Hydrocortisone

Catalog No.S1696

Hydrocortisone  Chemical Structure

Molecular Weight(MW): 362.46

Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland.
Targets
Glucocorticoid receptor [1]
()
In vitro

Hydrocortisone prevents endothelial barrier breakdown in response to pro-inflammatory stimuli (TNFalpha administration) in the human brain microvascular endothelial cell line hCMEC/D3, which could be demonstrated to be partly based on maintenance of occludin levels. [1] Hydrocortisone-treated dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibits production of IFN-gamma but induces an increased release of IL-4 and no change in IL-5. Hydrocortisone reduces T-cell proliferation in dendritic cells. [2] Hydrocortisone prevents TNF-alpha induced severe degradation of the glycocalyx, increased coronary resistance, heightened vascular leak and permeability to hydroxyethyl starch and caused mast-cell degranulation in isolated guinea pig hearts. [3] Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation in isolated guinea pig hearts. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan, as well as release of histamine from resident mast cells. [4] Hydrocortisone increases the levels of IL-4-induced germ line C epsilon transcripts by twofold and delivers the signal required for transcription of mature C epsilon mRNA. Hydrocortisone induces S mu-S epsilon deletional switch recombination in IL-4-treated B cells, and support a model of sequential isotype switching from IgM to IgE via IgG4. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse RAW264.7 cells MmjxSpVv[3Srb36gZZN{[Xl? MXKyOEBp NYPDSXFCSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFnGUk1o[W2vYTDpcoR2[2WmIF7PJJBzd2S3Y4Tpc44h[W[2ZYKgNlQhcHK|IHL5JGdzcWW|czDy[YFkfGmxbjygTWM2OD1yLkC2NUDPxE1? M3zZ[FIyOzZzM{O4
mouse L929 cells NG\XcWxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnzUOkBl[Xm| M1X1WWdzd3e2aDDpcohq[mm2aX;uJI9nKG2xdYPlJGw6OjliY3XscJMh[W[2ZYKgOkBl[Xm| MUC5NlYyOTN?

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Protocol

Solubility (25°C)

In vitro DMSO 73 mg/mL (201.4 mM)
Ethanol 23 mg/mL (63.45 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 362.46
Formula

C21H30O5

CAS No. 50-23-7
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01859312 Completed Adrenal Insufficiency|Excess Androgen|Congenital Adrenal Hyperplasia (CAH) National Institutes of Health Clinical Center (CC)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) May 6, 2013 Phase 2
NCT00097474 Completed Jet Lag Syndrome Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) November 22, 2004 Phase 2
NCT03007147 Not yet recruiting B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1|BCR-ABL1 Fusion Protein Expression|Minimal Residual Disease|Philadelphia Chromosome Positive|T Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia Childrens Oncology Group|National Cancer Institute (NCI) July 2017 Phase 3
NCT01422733 Not yet recruiting Hyperandrogenemia|Obesity|Polycystic Ovary Syndrome University of Virginia April 2017 --
NCT01422707 Not yet recruiting Hyperandrogenemia|Obesity|Polycystic Ovary Syndrome University of Virginia April 2017 --
NCT03020030 Not yet recruiting Acute Lymphoblastic Leukemia, Pediatric Dana-Farber Cancer Institute|Baxalta US Inc. January 2017 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID