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Gemcitabine Hydrochloride
(SynonymsGemzar
)Add to Favor
M.Wt: 299.66
Formula: C9H11F2N3O4.HCI
Solubility: DMSO
Purity: >99%
Storage: at -20℃ 2 years
CAS No.: 122111-03-9
Price and Availability of Gemcitabine Hydrochloride:
Applications & Customer's Feedback of Gemcitabine Hydrochloride:
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Gemcitabine was supplied by Selleck.Data was provided by Dr Helen Sadik of Johns Hopkins University.
Cells were seeded in 96 well paltes, and then treated with the indicated concentration of Gemcitabine for 48h. Cell survival was measured by a standarad MTT assay.
Biological Activity of Gemcitabine Hydrochloride:
Gemcitabine is a new pyrimidine chemotherapy drug that is given as a treatment for some types of cancer, such as non-small cell lung cancer, pancreatic, bladder and breast cancer|. [1]
Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. [2]
Gemcitabine inhibits proliferation BxPC-3 pancreatic cancer cell line with IC50 of 0.06 µM. [3]
References on Gemcitabine Hydrochloride:
[1] http://en.wikipedia.org/wiki/Gemcitabine
[2] http://www.cancer.gov/drugdictionary/?CdrID=41213
[3] Jeffrey L. Cleland et al. Proc Amer Assoc Cancer Res.2005,46
AntimetabolitesWe give free samples and rewards to people who would like to provide us useful scientific data(western blot, etc.) See Details
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