Molecular Weight(MW): 330.74
Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used in the treatment of congestive heart failure and edema.
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|Description||Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used in the treatment of congestive heart failure and edema.|
Furosemide reversibly alters the responses to tones and clicks of the chinchilla basilar membrane in hair cells, causing response-magnitude reductions that are largest (up to 61 dB, averaging 25-30 dB) at low stimulus intensities at the characteristic frequency (CF) and small or nonexistent at high intensities and at frequencies far removed from CF. Furosemide also induces response-phase lags that are largest at low stimulus intensities (averaging 77 degrees) and are confined to frequencies close to CF.  Furosemide concentration- and time-dependently increases the formation of nitric oxide andprostacyclin. Furosemide leads to an enhanced release of kinins into the supernatant of the cells.  Furosemide reversibly suppresses low Ca2+-induced epileptiform activity in hippocampus proper and blocks or significantly reduces different types of epileptiform discharges in the low Mg2+ model and the 4-aminopyridine model.  Furosemide significantly inhibits cell growth in MKN45 cells, but not in MKN28 cells. Furosemide diminishes cell growth by delaying the G(1)-S phase progression in poorly differentiated gastric adenocarcinoma cells, which show high expression and activity of NKCC, but not in moderately differentiated gastric adenocarcinoma cells with low expression and NKCC activity. 
|In vivo||Furosemide (0.25 to 2 mg/kg), administered 4 hours before exercise, reduces right atrial pressure (RAP) and pulmonary arterial pressure (PAP) during exercise in dose-dependent manner in horse. |
-  Charak BS, et al. J Antimicrob Chemother,?991, 27(1), 95-104.
-  Wiemer G, et al. J Pharmacol Exp Ther,?994, 271(3), 1611-1615.
-  Gutschmidt KU, et al. Neuroscience,?999, 91(4), 1471-1481.
|In vitro||DMSO||66 mg/mL (199.55 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03359161||Recruiting||Heart Failure||Steward St. Elizabeth''s Medical Center of Boston Inc.||April 5 2018||Phase 2|Phase 3|
|NCT03010475||Completed||Diabetes|Healthy||Novo Nordisk A/S||January 5 2017||Phase 1|
|NCT03093090||Not yet recruiting||Medication Absorption||Yale University||December 31 2018||Phase 1|
|NCT03103568||Completed||Drug Drug Interaction||Swedish Orphan Biovitrum|Parexel||March 28 2017||Phase 1|
|NCT03170219||Recruiting||Acute Heart Failure|Decompensated Heart Failure||Adrian Hernandez|Duke University||April 27 2018||Phase 2|
|NCT03307252||Completed||Healthy||Boehringer Ingelheim||October 25 2017||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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