Research Area
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Carboplatin Chemical Structure
Cisplatin
Potent anticancer agent that blocks DNA synthesis.
Nelarabine (Arranon)
Nelarabine(Arranon) performes growth inhibitory activity (IC50= 1.61 μM) against MOLT-4 cells
Bleomycin sulfate
A glycopeptide antibiotic produced by the bacterium Streptomyces verticillus.
Clafen (Cyclophosphamide)
This agent inhibited cell proliferation of NCI-H727 with IC50 at 9.3 nM.
Clofarabine
Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase
Oxaliplatin (Eloxatin)
Oxaliplatin (Eloxatin) is a 1,2-diaminocyclohexane (DACH) carrier ligand-based groups of platinum antitumor agent with IC50 of median 1.3, 6.2 and 1.5 mM for SW480 DLD1, HT29, respectively.
CCT239065
CCT239065 is a novel, selective, and efficacious nanomolar pyridopyrazinone V600E BRAF and LCK inhibitor with IC50 of 13 nM and 6 nM, respectively.
NSC-207895 (XI-006)
NSC-207895 (XI-006) is a derivative of nitrobenzofuroxan and an anticancer agent with an EC50 of 1 μM.
CX-5461
CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 μM.
ABT-888 (Veliparib)
ABT-888 (Veliparib) is a potent poly (ADP-ribose) polymerase (PARP) inhibitor of PARP-1 and PARP-2 with Ki of 5.2 nM and 2.9 nM, respectively.
Biological Activity
Carboplatin is a second-generation platinum compound with a broad spectrum of antineoplastic properties. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. [1]
Carboplatin is used against some forms of cancer (mainly ovarian carcinoma, lung, head and neck cancers). [2]
This drug performed growth inhibitory activity in IGROV1 and OAW42 cells(IC50 of 25 and 30 mg/l, respectively) [3]
Product Information
| Molecular Weight (WM): | 371.25 |
|---|---|
| Formula: | C6H12N2O4Pt |
| CAS No.: | 41575-94-4 |
| Synonyms: |
Paraplatin
|
| Dissolve in (25°C): | DMSO <1mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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Notes:
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A. MCF10A-Ras overexpressing a vector control or the gene of interest (GeneX), or MCF7 expressing a scramble or a siRNA for the geneX were treated with DMSO or with Carboplatin for 24h. Resistant colonies were allowed to grow for 2 weeks, and are then stained with Crystal Violet. B. Quantification of the results.
A. MCF10A-Ras overexpressing a vector control or the gene of interest (GeneX), or MCF7 expressing a scramble or a siRNA for the geneX were treated with DMSO or with Carboplatin for 24h. Resistant colonies were allowed to grow for 2 weeks, and are then stained with Crystal Violet. B. Quantification of the results.
Data independently produced by Dr Helen Sadik of Johns Hopkins University Carboplatin purchased from Selleck
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Click to enlarge
Cells were seeded in 96 well paltes, and then treated with the indicated concentration of Carboplatin for 48h. Cell survival was measured by a standarad MTT assay.
Cells were seeded in 96 well paltes, and then treated with the indicated concentration of Carboplatin for 48h. Cell survival was measured by a standarad MTT assay.
Data independently produced by Dr Helen Sadik of Johns Hopkins University Carboplatin purchased from Selleck
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A. MCF10A-Ras overexpressing a vector control or the gene of interest (GeneX), or MCF7 expressing a scramble or a siRNA for the geneX were treated with DMSO or with Carboplatin for 24h. Resistant colonies were allowed to grow for 2 weeks, and are then stained with Crystal Violet. B. Quantification of the results.
|
Data independently produced by Dr Helen Sadik of Johns Hopkins University
Cells were seeded in 96 well paltes, and then treated with the indicated concentration of Carboplatin for 48h. Cell survival was measured by a standarad MTT assay.
|
Data independently produced by Dr Helen Sadik of Johns Hopkins University
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