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Calcifediol

Name: Calcifediol
Brand: Selleck Chemicals
SKU: S1469
Rating: 5 (12 reviews)

Synonyms: Calcidiol, Didrogyl, Hidroferol, 25-hydroxyvitamin D3, 25-Hydroxycholecalciferol

Catalog No.S1469 Purity: 99.96%

Calcifediol (Calcidiol, Didrogyl, Hidroferol, 25-hydroxyvitamin D3, 25-Hydroxycholecalciferol) is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It also suppresses PTH secretion and mRNA (ED50=2 nM).

Calcifediol Chemical Structure

CAS: 19356-17-3

Selleck's Calcifediol has been cited by 12 Publications

1 Customer Review

Purity & Quality Control

Batch: Purity: 99.96%

99.96

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Biological Activity

Description	Calcifediol (Calcidiol, Didrogyl, Hidroferol, 25-hydroxyvitamin D3, 25-Hydroxycholecalciferol) is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It also suppresses PTH secretion and mRNA (ED50=2 nM).

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05732883	Not yet recruiting	Voice Change\|Hypocalcemia	Tseung Kwan O Hospital Hong Kong\|United Christian Hospital\|Chinese University of Hong Kong	January 1 2024	Phase 2
NCT05540678	Recruiting	Nutritional and Metabolic Diseases\|Child Obesity\|Adolescent Obesity	Insel Gruppe AG University Hospital Bern\|DCB Research AG	November 30 2022	Not Applicable
NCT05819918	Completed	COVID-19	Maimónides Biomedical Research Institute of Córdoba	April 1 2022	--
NCT04386850	Unknown status	COVID 19	Tehran University of Medical Sciences\|Boston University	April 14 2020	Phase 2\|Phase 3
NCT03660800	Completed	Vitamin D Insufficiency\|Secondary Hyperparathyroidism	OPKO Health Inc.	August 20 2018	Phase 1
NCT04392986	Completed	Sunlight Exposure	Korea University Anam Hospital	June 1 2018	Not Applicable

Chemical Information & Solubility

Molecular Weight	400.64	Formula	C₂₇H₄₄O₂
CAS No.	19356-17-3	SDF	Download Calcifediol SDF
Smiles	CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 80 mg/mL ( (199.68 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 80 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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