Budesonide

Catalog No.S1286

Budesonide Chemical Structure

Molecular Weight(MW): 430.53

Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.

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Biological Activity

Description Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.
Targets
Glucocorticoid receptor [1]
()
In vitro

Budesonide effectively inhibits production of eotaxin and RANTES protein although Budesonide inhibits the expression of chemokine mRNA to a variable extent in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. Budesonide inhibits both RANTES- and eotaxin promoter-driven reporter gene activity in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. Budesonide also selectively accelerates the decay of eotaxin and MCP-4 mRNA in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. [1] Budesonide time- and protein synthesis-dependently reduces VEGF secretion and VEGF mRNA expression in both cell types and these effects are inhibited by mifepristone (RU 486), a glucocorticoid receptor antagonist, suggesting that Budesonide reduces VEGF secretion and expression through its glucocorticoid receptor-mediated action. [2] Budesonide causes a dose-dependent, almost total, inhibition of swine dust-induced IL-6 and IL-8 release from epithelial cells and LPS-induced IL-6 and TNF-alpha from alveolar macrophages. [3]

In vivo Budesonide totally prevents the increased production of TNF-alpha, interleukin (IL)-1beta, IL-6, and monocyte chemoattractive protein (MCP)-1 after LPS challenge at both low (2.5 mg/mL/kg) and high (50 mg/mL/kg) concentrations in rats. [4] Budesonide exerts its effects of chemoprevention through growth arrest via Mad2/3 and through apoptosis via Bim/Blk and, by inference, caspase-8/9 in A/J mice. [5]

Protocol

Solubility (25°C)

In vitro DMSO 86 mg/mL (199.75 mM)
Ethanol 19 mg/mL (44.13 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 430.53
Formula

C25H34O6

CAS No. 51333-22-3
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01950507 Recruiting Stem Cell Transplantation|Graft vs Host Disease National Institutes of Health Clinical Center (CC)|National Heart, Lung, and Blood Institute (NHLBI) August 31, 2013 Phase 1
NCT02853578 Not yet recruiting Asthma Ache Laboratorios Farmaceuticos S.A. March 2018 Phase 3
NCT02972866 Not yet recruiting Rhinitis, Allergic, Perennial Eurofarma Laboratorios S.A. October 2017 Phase 3
NCT01895075 Not yet recruiting Bronchopulmonary Dysplasia Dr. Michael Dunn|Sunnybrook Health Sciences Centre July 2017 Phase 2
NCT02941510 Not yet recruiting Altitude Sickness University of Colorado, Denver April 2017 Phase 3
NCT02991859 Not yet recruiting Asthma GlaxoSmithKline February 2017 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID