Betamethasone

Catalog No.S1500 Synonyms: NSC-39470, SCH-4831

Betamethasone  Chemical Structure

Molecular Weight(MW): 392.46

Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
Targets
Glucocorticoid receptor [1]
()
In vitro

Betamethasone has a specific affinity for type II glucocorticoid receptors which are present in most brain regions. [1]

In vivo Betamethasone has direct vasoconstrictor effects on peripheral femoral resistance vessels in late gestation fetal sheep. Betamethasone exposure decreases cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 hours of infusion in sheep. [1] Betamethasone reduces the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induces the expression of IL-10 in the brain, all of which correlate with the changes of pain thresholds in rats. [2] Betamethasone exposure reduces synaptophysin-LI in the frontal neocortex, caudate putamen and hippocampus by 46.9%, 41.0% and 55.4%, respectively, that is not accompanied by irreversible neuronal damage in the fetal sheep brain. [3] Betamethasone modestly increases cytidylyltransferase (CT) mRNA, but does not alter the levels of immunoreactive enzyme in adult rat lung. Betamethasone decreases the activities of the sphingomyelin hydrolases: acid sphingomyelinase by 33% and of alkaline ceramidase by 21%. [4] Betamethasone injected at the time of nerve injury partially inhibits the development of neuropathic hyperalgesia and reduces the subsequent elevated levels of pro-inflammatory cytokines in the brain of rats, while stimulating the expression of the anti-inflammatory cytokine IL-10. [5]

Protocol

Solubility (25°C)

In vitro DMSO 79 mg/mL (201.29 mM)
Ethanol 10 mg/mL (25.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.46
Formula

C22H29FO5

CAS No. 378-44-9
Storage powder
Synonyms NSC-39470, SCH-4831

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02582177 Not yet recruiting Tinea Ache Laboratorios Farmaceuticos S.A. August 2017 Phase 3
NCT03020199 Not yet recruiting Plaque Psoriasis Novartis Pharmaceuticals|Novartis January 2017 Phase 4
NCT02897076 Recruiting Neonatal Complications Assistance Publique - Hôpitaux de Paris January 2017 Phase 3
NCT02978976 Recruiting Neonatal Respiratory Distress Kasr El Aini Hospital November 2016 Phase 4
NCT02939742 Not yet recruiting PPROM|Respiratory Distress Syndrome in Premature Infants The University of Texas Medical Branch, Galveston November 2016 Phase 2|Phase 3
NCT02940002 Active, not recruiting Psoriasis Bayer October 2016 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID