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AChR Inhibitors & Chemicals

AChR Inhibitors & Chemicals (38)
water-soluble

Cat.No.	Product Name	Information
S2497	Pancuronium (Pavulon)	Pancuronium (Pavulon) is a competitive acetylcholine antagonist with an IC50 of 5.5 ± 0.5 nM.
S2550	Tolterodine tartrate (Detrol LA)	Tolterodine tartrate (Detrol LA) is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist.
S1248	Vinblastine	Vinblastine inhibits microtubule formation and supresses nAChR activity with IC50 of 8.9 μM.
S2462	Donepezil HCl (Aricept)	Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.
S1339	Galanthamine HBr	Galanthamine (Razadyne, Reminyl) is an AChE inhibitor with IC50 of 14 nM.
S4034	Diphemanil Methylsulfate	Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).
S4024	Homatropine Methylbromide	Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
S4025	Homatropine Bromide	Homatropine Bromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
S4027	Flavoxate HCl	Flavoxate is a muscarinic AChR antagonist with IC50 of 12.2 μM.
S4031	Aclidinium Bromide	Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with K_i of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.
S4014	Hyoscyamine (Daturine)	Hyoscyamine (Daturine) is an AChR inhibitor with IC50 of 7.5 nM.
S1608	Pyridostigmine Bromide (Mestinon)	Pyridostigmine Bromide(Mestinon) is a parasympathomimetic and a reversible cholinesterase inhibitor.
S1754	Oxybutynin(Ditropan)	Oxybutynin(Ditropan) is an anticholinergic medication used to relieve urinary and bladder difficulties.
S2087	Rivastigmine tartrate (Exelon)	Rivastigmine, a cholinesterase inhibitor with IC50 of 5.5 μM, ues as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.
S2054	Orphenadrine citrate (Norflex)	Orphenadrine citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.
S1913	Tropicamide	Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.
S2659	5-hydroxymethyl tolterodine (PNU 200577)	5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with K_b of 0.84 nM.
S3048	Solifenacin succinate	Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class.
S3047	Otilonium Bromide	Otilonium bromide is an antimuscarinic.
S3144	Darifenacin HBr	Darifenacin is a selective M3 muscarinic receptor antagonist with pK_i of 8.9.
S3117	Oxybutynin chloride	Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.
S2614	Arecoline	Arecoline is a muscarinic acetylcholine receptor agonist.
S2629	PNU-120596	PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM in α7^*-expressing SH-EP1 cells.
S2240	Fesoterodine fumarate (Toviaz)	Fesoterodine fumarate (Toviaz) is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.
S2547	Tiotropium Bromide hydrate	Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.
S2549	Trospium chloride (Sanctura)	Trospium chloride (Sanctura) is a competitive muscarinic cholinergic receptor antagonist.
S2508	Scopolamine HBr	Scopolamine hydrobromide is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM.
S2455	Bethanechol chloride	Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors.
S2471	Gallamine triethiodide (Flaxedil)	Gallamine triethiodide(Flaxedil) is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM.
S2490	Neostigmine bromide (Prostigmin)	Neostigmine bromide(Prostigmin) is a reversible acetylcholinesterase inhibitor.
S2130	Atropine	Atropine sulfate monohydrate is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 2.5 nM.
S1978	Methscopolamine (Pamine)	Methscopolamine (Pamine) is a muscarinic acetylcholine receptor blocker.
S1929	Irsogladine	Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
S1805	Acetylcholine chloride	The chemical compound acetylcholine (ACh) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.
S1623	Acetylcysteine	Acetylcysteine is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose.
S1440	Varenicline tartrate	Varenicline is a prescription medication used to treat smoking addiction.
S1397	Rocuronium bromide	Rocuronium is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant.
S1285	Biperiden HCl	Biperiden is an antiparkinsonian agent of the anticholinergic type.

Inhibitory Selectivity
Solubility

Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S2497	Pancuronium (Pavulon)	147 mg/mL	147 mg/mL	147 mg/mL
S2550	Tolterodine tartrate (Detrol LA)	17 mg/mL	95 mg/mL	6 mg/mL
S1248	Vinblastine	<1 mg/mL	68 mg/mL	6 mg/mL
S2462	Donepezil HCl (Aricept)	31 mg/mL	1 mg/mL	2 mg/mL
S1339	Galanthamine HBr	36 mg/mL	<1 mg/mL	<1 mg/mL
S4034	Diphemanil Methylsulfate	28 mg/mL	25 mg/mL	<1 mg/mL
S4024	Homatropine Methylbromide	74 mg/mL	74 mg/mL	10 mg/mL
S4025	Homatropine Bromide	71 mg/mL	71 mg/mL	<1 mg/mL
S4027	Flavoxate HCl	10 mg/mL	3 mg/mL	<1 mg/mL
S4031	Aclidinium Bromide	<1 mg/mL	113 mg/mL	<1 mg/mL
S4014	Hyoscyamine (Daturine)	<1 mg/mL	58 mg/mL	58 mg/mL
S1608	Pyridostigmine Bromide (Mestinon)	52 mg/mL	52 mg/mL	52 mg/mL
S1754	Oxybutynin(Ditropan)	<1 mg/mL	72 mg/mL	72 mg/mL
S2087	Rivastigmine tartrate (Exelon)	80 mg/mL	42 mg/mL	80 mg/mL
S2054	Orphenadrine citrate (Norflex)	<1 mg/mL	92 mg/mL	<1 mg/mL
S1913	Tropicamide	<1 mg/mL	57 mg/mL	57 mg/mL
S2659	5-hydroxymethyl tolterodine (PNU 200577)	<1 mg/mL	68 mg/mL	68 mg/mL
S3048	Solifenacin succinate	96 mg/mL	3 mg/mL	5 mg/mL
S3047	Otilonium Bromide	113 mg/mL	113 mg/mL	113 mg/mL
S3144	Darifenacin HBr	<1 mg/mL	117 mg/mL	<1 mg/mL
S3117	Oxybutynin chloride	4 mg/mL	79 mg/mL	79 mg/mL
S2614	Arecoline	47 mg/mL	47 mg/mL	10 mg/mL
S2629	PNU-120596	<1 mg/mL	62 mg/mL	1 mg/mL
S2240	Fesoterodine fumarate (Toviaz)	106 mg/mL	106 mg/mL	106 mg/mL
S2547	Tiotropium Bromide hydrate	<1 mg/mL	8 mg/mL	<1 mg/mL
S2549	Trospium chloride (Sanctura)	86 mg/mL	41 mg/mL	42 mg/mL
S2508	Scopolamine HBr	77 mg/mL	77 mg/mL	18 mg/mL
S2455	Bethanechol chloride	39 mg/mL	39 mg/mL	39 mg/mL
S2471	Gallamine triethiodide (Flaxedil)	178 mg/mL	178 mg/mL	<1 mg/mL
S2490	Neostigmine bromide (Prostigmin)	61 mg/mL	<1 mg/mL	<1 mg/mL
S2130	Atropine	139 mg/mL	139 mg/mL	139 mg/mL
S1978	Methscopolamine (Pamine)	80 mg/mL	80 mg/mL	<1 mg/mL
S1929	Irsogladine	<1 mg/mL	2 mg/mL	<1 mg/mL
S1805	Acetylcholine chloride	36 mg/mL	36 mg/mL	36 mg/mL
S1623	Acetylcysteine	33 mg/mL	33 mg/mL	33 mg/mL
S1440	Varenicline tartrate	72 mg/mL	1 mg/mL	<1 mg/mL
S1397	Rocuronium bromide	122 mg/mL	122 mg/mL	122 mg/mL

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AChR Inhibitors & Chemicals

AChR Inhibitors & Chemicals (38)water-soluble

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AChR Inhibitors & Chemicals (38)
water-soluble