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S1208
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Doxorubicin (Adriamycin) |
Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. |
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S1225
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Etoposide (VP-16) |
Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. |
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S1231
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Topotecan HCl |
Topotecan (Hycamtin, NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively. |
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S1288
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Camptothecin |
Camptothecin (Camptohecine, 20-(S)-Camptothecin, CPT, NSC100880) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM. |
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S1198
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Irinotecan |
Irinotecan (Camptosar, Campto, CPT-11) is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. |
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S4908
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SN-38 |
SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I. |
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S1223
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Epirubicin HCl |
Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase. |
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S2217
|
Irinotecan HCl Trihydrate (Campto) |
Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. |
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S3181
|
Flumequine |
Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 μM. |
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S1889
|
Mitoxantrone |
Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively |
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S1463
|
Ofloxacin (Floxin) |
Ofloxacin is a synthetic broad-spectrum antimicrobial agent. |
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S1465
|
Moxifloxacin HCl |
Moxifloxacin(Avelox, Avalox) is a fourth generation synthetic fluoroquinolone antibacterial agent. |
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S1393
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Pirarubicin |
Pirarubicin is an anthracycline agent. |
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S1367
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Amonafide |
Amonafide (NSC-308847) is a selective topoisomerase II inhibitor. |
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S1327
|
Ellagic acid |
Ellagic acid has antiproliferative and antioxidant property. |
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S1342
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Genistein |
Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. |
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S1228
|
Idarubicin HCl |
Idarubicin HCl (Idamycin, Zavedos, 4-demethoxydaunorubicin) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL. |
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