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Topoisomerase

Cat.No.	Product Name	Added

S1208	Adriamycin (Doxorubicin)	May 2010
Adriamycin (Doxorubicin) is a topoisomerase II inhibitor with IC50 of 1 and 2 μM for the inhibition of MCF-7 and MDA-MB231.

S1288	Camptothecin	Jun 2010
Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I (topo I) with an IC50 and IC70 of 50 nM and 0. 225 μM .

S1216	Cerubidine	May 2010
Cerubidine (Daunorubicin) is the hydrochloride salt of an anthracycline cytotoxic antibiotic produced by a strain of Streptomyces coeruleorubidus (IC50=0.5μM).

S1223	Epirubicin Hydrochloride	May 2010
Epirubicin Hydrochloride (Ellence) is an anthracyclin antibiotics and a DNA topoisomerase II inhibitor with an IC50 of 12 μg/ml on an estrogen-receptor- positive ER (+) hyperdiploid EAT cell line.

S1225	Etoposide (Etopophos)	May 2010
Etoposide (Etopophos) is a Topoisomerase II inhibitor (IC50 = 59.2 μM).

S1228	Idarubicin HCl	May 2010
Idarubicin is the anthracycline antibiotic and target DNA topoisomerase II (topo II). MCF-7 cells were sensitive to idarubicin, with an IC 50 value for growth inhibition of 0.01 μM

S1198	Irinotecan	May 2010
Irinotecan is a topoisomerase I inhibitor with an IC50 of 15.8 and 5.17 μM for LoVo cells and HT-29 cells, respectively.

S2217	Irinotecan HCl Trihydrate (Campto)	Mar 2011
Irinotecan hydrochloride trihydrate is a hydrochloride trihydrate of irinotecan (Camptosar, Campto, CPT-11) which is a topoisomerase I inhibitor with IC50 of 15.8 and 5.17 μM for LoVo cells and HT-29 cells, respectively.

S2485	Mitoxantrone	Jan 2011
Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 µM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively.

S1231	Topotecan Hydrochloride	May 2010
Topotecan Hydrochloride (Hycamtin) is a topoisomerase I inhibitor with an IC50 of 13 and 2 nM for MCF-7 Luc cells and DU-145 Luc cells.