Cell Cycle / Checkpoint

The term ‘Cell-Cycle Checkpoint’ refers to mechanisms by which the cell actively halts progression through the cell cycle until it can ensure that an earlier process, such as DNA replication or mitosis, is complete. The cell cycle and cell cycle-associated proteins play essential roles in cell fate, including cell replication, cell death, and cell function. Cell cycle-check point includes many targets such as CDK, ROCK, Topoisomerase, Antimetabolites and Microtubule. Some CDK inhibitors such as AT7519 can inhibit CDKs to inhibit tumor cell proliferation by promoting cell cycle arrest and apoptosis. Some Topoisomerase inhibitors such as Cerubidine can bind to the the minor groove of DNA to inhibit topoisomerase and result in DNA damage to suppress cancer cell line. Many researchers pay attention to AZD7762, a Checkpoint inhibitor because it can be used in combination with cytotoxic agents or radiation to treatsolid tumors. Recently, Roscovitine (CYC202), a CDK inhibitor, is used by researchers to investigate the relationship between CDK and Androgen receptor phosphorylation, dopaminergic and glutamatergic transmission, NMDA receptors which published in Proc Natl Acad Sci USA.