+ Product Pathways
- All Targets
- Angiogenesis/Tyrosine Kinase
- Cell Cycle/Checkpoint
- HDAC
- Apoptosis
- PARP
- Aurora/Ksp
- MAPK
- PI3K/Akt/mTOR
- Hormone
- Integrase/CCR5
- Proteases/HSP90/HSP70
- Wnt/Hedgehog/Notch
- Jak/Stat
- Ca/cAMP/Lipid Signaling
- Neuro Signaling
- TGF-beta/Smad Signaling
- GPCR
- Ion channel
- Cytochrome P450
- Others
- Cancer
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Recent Published Papers
with Selleck Products
Diminished sensitivity of Chronic Lymphocytic Leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood
Meike Vogler, Silviya D Furdas, Manfred Jung, Tomomi Kuwana, Martin JS Dyer and Gerald M Cohen.
[American Association for Cancer Research,Published OnlineFirst on July 2, 2010; DOI:10.1158/1078-0432.CCR-10-0777]
ABT-263 purchased from Selleck Chemicals.
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
Sarah R. Walmsley, Edwin R. Chilvers, Alfred A. Thompson, Kathryn Vaughan, Helen M. Marriott, Lisa C. Parker, Gary Shaw, Selina Parmar et al.
[The Journal of Clinical Investigation; DOI::10.1172/JCI43273]
ABT-737 purchased from Selleck Chemicals.
The BH3-mimetic ABT-737 targets the apoptotic machinery in cholangiocarcinoma cell lines resulting in synergistic interactions with zoledronic acid
Antonello A. Romani,Silvia Desenzani,Marina M. Morganti,Maria Cristina Baroni,Angelo F. Borghetti and Paolo Soliani.
[Cancer Chemotherapy and Pharmacology; DOI:10.1007/s00280-010-1345-6]
ABT-737 purchased from Selleck Chemicals.
Glycogen synthase kinase−3β inhibitors suppress leukemia cell growth
Emma Y. Song,Patricia Palladinetti,Guy Klamer,Kap-Hyoun Ko,Robert Lindeman,Tracey A. O'Briena,bandAlla Dolnikov,
[Experimental Hematology.June 9 2010; DOI:10.1016/j.exphem.2010.06.001]
ABT-737 purchased from Selleck Chemicals.
p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress
Esteban N. Gurzov, Carla M. Germano, Daniel A. Cunha, Fernanda Ortis, Jean-Marie Vanderwinden,Piero Marchetti, Lin Zhang, and Decio L. Eizirik.
[JOURNAL OF BIOLOGICAL CHEMISTRY.JUNE 25 2010.VOLUME 285.NUMBER 26(P19910-19920)]
ABT-737 purchased from Selleck Chemicals.
ABT-737 Overcomes Resistance to Immunotoxin-Mediated Apoptosis and Enhances the Delivery of Pseudomonas Exotoxin–Based Proteins to the Cell Cytosol
Roberta Traini, Gal Ben-Josef, Diana V. Pastrana, Elizabeth Moskatel, Ashima K. Sharma,Antonella Antignani, and David J. FitzGerald,
[Molecular Cancer Therapeutics; DOI:10.1158/1535-7163.MCT-10-0257]
ABT-737 purchased from Selleck Chemicals.
Histone deacetylase inhibitors synergistically potentiate death receptor 4-mediated apoptotic cell death of human T-cell acute lymphoblastic leukemia cells
Eun-Sil Sung , Aeyung Kim, Joon Seong Park, Junho Chung, Myung-Hee Kwon, Yong-Sung Kim
[Apoptosis.JUNE 26, 2010. DOI:10.1007/s10495-010-0521-9]
ABT-737 purchased from Selleck Chemicals.
PUMA ACTIVATION CONTRIBUTES TO PANCREATIC BETA CELL APOPTOSIS INDUCED BY PRO-INFLAMMATORY CYTOKINES AND ENDOPLASMIC RETICULUM STRESS
Esteban N. Gurzov, Carla M. Germano, Daniel A. Cunha et al.
[The Journal of Biological Chemistry,2010 June;285(19910-19920). DOI:10.1074/jbc.M110.122374]
ABT-737 purchased from Selleck Chemicals.
Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability
Daniel Corta´zar, Christophe Kunz, Jim Selfridge, Teresa Lettieri, Yusuke Saito, Eilidh MacDougall, Annika Wirz et al.
[NATURE; DOI:10.1038/nature09672]
AG-014699 purchased from Selleck Chemicals.
Vitamin D receptor regulation of cholesterol 7α-Hydroxylase gene transcription and bile acid synthesis in human hepatocytes.
Shuxin Han.
[A dissertation submitted to Kent State University in partial fulfillment of the requirements for the degree of Doctor of Philosophy.]
AZD0530 purchased from Selleck Chemicals.
Systems-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma.
Olena Morozova, Milijana Vojvodic,Natalie Grinshtein, Loen M. Hansford,Kim M. Blakely, Alexandra Maslova, Martin Hirst, Timothee Cezard et al.
[Clinical Cancer Research; DOI:10.1074/jbc.M110.198804]
AZD1152 purchased from Selleck Chemicals.
MSH3 mediates sensitization of colorectal cancer cells to cisplatin, oxaliplatin and a poly(adp-ribose) polymerase inhibitor
Masanobu Takahashi, Minoru Koi, Francesc Balaguer, C. Richard Boland and Ajay Goel
[JBC Papers in Press; DOI:10.1158/1078-0432.CCR-10-0627]
AZD2281 purchased from Selleck Chemicals.
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
RaminNazarian,Hubing Shi, QiWang, XiangjuKong, Richard C.Koya, Hane Lee, Zugen Chen, Mi-Kyung Lee, et al.
[Nature; DOI:10.1038/nature09626]
AZD6244 purchased from Selleck Chemicals.
Vertical Targeting of the Phosphatidylinositol-3 Kinase Pathway as a Strategy for Treating Melanoma
Saadia A. Aziz, Lucia B. Jilaveanu, Christopher Zito, et al.
[Clin Cancer Res 2010; DOI:10.1158/1078-0432.CCR-10-1490]
AZD6244 purchased from Selleck Chemicals.
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
Cory M. Johannessen, Jesse S. Boehm, So Young Kim, Sapana R. Thomas, et al.
[N AT U R E Published online24 November 2010; DOI:10.1038/nature09627]
AZD6244 | BEZ235(Synonyms NVP-BEZ235) purchased from Selleck Chemicals.
MEK1 mutations confer resistance to Mek and B-RAF inhibition
Caroline M. Emery, Krishna G. Vijayendran, Marie C. Zipser, Allison M. Sawyer, Lili Niu, et al.
[Proc Natl Acad Sci USA.Dec 1 2009; DOI:10.1073/pnas.0905833106]
AZD6244 purchased from Selleck Chemicals.
Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo
Kihyun Kim, Sun-Young Kong,1Mariateresa Fulciniti, Xianfeng Li,Weihua Song, Sabikun Nahar, et al.
[British Journal of Haematology. 2010; DOI:10.1111/j.1365-2141.2010.08127.x]
AZD6244 purchased from Selleck Chemicals.
Activation of FOXO3a Is Sufficient to Reverse Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor Chemoresistance in Human Cancer
Jer-Yen Yang, Chun-Ju Chang, Weiya Xia, Yan Wang, Kwok-Kin Wong, et al.
[Cancer Res; 70(11) June 1, 2010; DOI:10.1158/0008-5472.CAN-09-4524]
AZD6244 | BEZ235(NVP-BEZ235) purchased from Selleck Chemicals.
Correlating Phosphatidylinositol 3-Kinase Inhibitor Efficacy with Signaling Pathway Status: In silico and Biological Evaluations
Shingo Dan, Mutsumi Okamura, Mariko Seki, Kanami Yamazaki, Hironobu Sugita,Michiyo Okui, Yumiko Mukai, Hiroyuki Nishimura, Reimi Asaka,Kimie Nomura, Yuichi Ishikawa, and Takao Yamori.
[Cancer Research.June 15 2010.(P4983-4994); DOI:10.1158/0008-5472.CAN-09-4172]
BEZ235(NVP-BEZ235) purchased from Selleck Chemicals.
Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39.
Dexin Kong,Shingo Dan,Kanami Yamazaki and Takao Yamori.
[EUROPEAN JOURNAL OF CANCER 46(2010); DOI:10.1016/j.ejca.2010.01.005]
BEZ235(NVP-BEZ235) purchased from Selleck Chemicals.
Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55a,d Phosphatase
Eusebio Manchado, Marı´a Guillamot, Guillermo de Ca´ rcer, Manuel Eguren, Michelle Trickey, Irene Garcı´a-Higuera, et al
[Cancer Cell 18, 641–654, December 14, 2010; DOI:10.1016/j.ccr.2010.10.028]
BI 2536 purchased from Selleck Chemicals.
Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells
Natalie Grinshtein, Alessandro Datti, Mayumi Fujitani, et al.
[Cancer Res 2011; DOI:10.1158/0008-5472.CAN-10-2484]
BI 2536 purchased from Selleck Chemicals.
Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia.
MW Harr, PF Caimi, KS McColl, F Zhong, SN Patel, PM Barr and CW Distelhorst.
[Cell Death and Differentiation (2010).]
BIBF1120 purchased from Selleck Chemicals.
PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival.
Irie HY, Shrestha Y, Selfors LM, Frye F, Iida N et al.
[PLoS ONE 5(7): e11729. DOI:10.1371/journal.pone.0011729]
BMS-536924 purchased from Selleck Chemicals.
Rotavirus replication requires a functional proteasome for effective assembly of viroplasms
Contin, R.; Arnoldi, F.; Mano, M.; Burrone O. R.
[JOURNAL OF VIROLOGY; DOI:10.1128/JVI.01631-10.]
Bortezomib purchased from Selleck Chemicals.
The clinically approved proteasome inhibitor PS-341 efficiently blocks influenza A virus and vesicular stomatitis virus propagation by establishing an antiviral state
Sabine Eva Dudek, Christina Luig, Eva-Katharina Pauli, et al.
[Journal of Virology.Prepublished June 30 2010; DOI:10.1128/JVI.00533-10.]
Bortezomib purchased from Selleck Chemicals.
Hepatitis B virus induces expression of antioxidant response element (ARE)-regulated genes by activation of Nrf2
Stephanie Schaedler, Janis Krause, Kiyoshi Himmelsbach, et al.
[JBC.First Published on October 18, 2010; DOI:10.1074/jbc.M110.145862]
Bortezomib purchased from Selleck Chemicals.
Inhibition of ser/thr phosphatases induces capacitation-associated signaling in the presence of Src kinase inhibitors.
Krapf D, Arcelay E, Wertheimer EV, Sanjay A, Pilder SH, Salicioni AM, Visconti PE.
[J Biol Chem. Jan 12,2010.]
Bosutinib(SKI-606) purchased from Selleck Chemicals.
VEGFR2 and Src Kinase Inhibitors Suppress ANDV Induced Endothelial Cell Permeability.
Elena E. Gorbunova, Irina N. Gavrilovskaya, Timothy Pepini, Erich R. Mackow.
[JVI; DOI:10.1128/JVI.02319-10]
Bosutinib(SKI-606) | Dasatinib | Pazopanib Hydrochloride purchased from Selleck Chemicals.
Tumor Necrosis Factor-like Weak Inducer of Apoptosis and Fibroblast Growth Factor-inducible 14 Mediate Cerebral Ischemia-induced Poly(Adp-ribose) Polymerase-1 Activation and Neuronal Death.
W. B. HAILE, R. ECHEVERRY, F. WU, J. GUZMAN, J. AN, J. WU and M. YEPES.
[euroscience 171 (2010) 1256–1264; DOI:10.1016/j.neuroscience.2010.10.029]
BSI-201 purchased from Selleck Chemicals.
The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11)
Bartosz Wasag, Els Lierman, Peter Meeus, Jan Cools, and Peter Vandenberghe
[Haematologica 2010; DOI:10.3324/haematol.2010.036558]
CHIR-258(Dovitinib) purchased from Selleck Chemicals.
Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo
FR Lamont, DC Tomlinson, PA Cooper, SD Shnyder, JD Chester and MA Knowles
[British Journal of Cancer (2010)]
CHIR-258(Dovitinib) purchased from Selleck Chemicals.
The fibroblast-derived paracrine factor neuregulin-1 has a novel role in regulating the constitutive color and melanocyte function in human skin.
Wonseon Choi, Rainer Wolber, Wolfram Gerwat, Tobias Mann, Jan Batzer, et al.
[Journal of Cell Science.4 June 2010; DOI:10.1242/jcs.064774]
CI-1033 purchased from Selleck Chemicals.
Dasatinib Plus Nutlin-3 Shows Synergistic Antileukemic Activity in Both p53wild-type and p53mutated B Chronic Lymphocytic Leukemias by Inhibiting the Akt Pathway
Giorgio Zauli, Rebecca Voltan, Raffaella Bosco, et al.
[Clin Cancer Res 2011; DOI:10.1158/1078-0432.CCR-10-2572]
Dasatinib purchased from Selleck Chemicals.
Anti-leukemic activity of Dasatinib in both p53wild-type and p53mutated B malignant cells
Raffaella Bosco, Marco Rabusin, Rebecca Voltan, et al.
[Invest New Drugs 2010; DOI:10.1007/s10637-010-9564-6]
Dasatinib purchased from Selleck Chemicals.
Molecular Characterization of c-Abl/c-Src Kinase Inhibitors Targeted against Murine Tumour Progenitor Cells that Express Stem Cell Markers
Thomas Kruewel, Silvia Schenone, Marco Radi, et al.
[PLoS ONE,November 30, 2010; DOI:10.1371/journal.pone.0014143]
Dasatinib | Imatinib Mesylate purchased from Selleck Chemicals.
Inhibition of glycogen biosynthesis via mTORC1 suppression as an adjunct therapy for Pompe disease
Karen M. Ashe, Kristin M. Taylor, Qiuming Chu, Elizabeth Meyers, Allen Ellis, Varvara Jingozyan, et al.
[Molecular Genetics and Metabolism.May 5 2010; DOI:10.1016/j.ymgme.2010.05.001]
Deforolimus(AP23573) | Temsirolimus(CCI-779) supplied by Selleck Chemicals.
Potential of novel antiretrovirals to modulate expression and function of drug transporters in vitro
Nadine Ce´ cile Luise Zembruski, Gabriele Bu¨ chel, Lisa Jo¨dicke, Melanie Herzog, Walter Emil Haefeli and Johanna Weiss
[J Antimicrob Chemother; DOI:10.1093/jac/dkq501]
Elvitegravir(GS-9137) purchased from Selleck Chemicals.
Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors.
Robert A Smith, Geoffrey S Gottlieb, A Dusty Miller.
[Retrovirology 2010; DOI:10.1186/1742-4690-7-70]
Elvitegravir(GS-9137) purchased from Selleck Chemicals.
Identification and characterization of persistent intracellular human immunodeficiency virus type 1 integrase strand transfer inhibitor activity.
Yasuhiro Koh, Hillel Haim and Alan Engelman.
[AAC Accepts, published online ahead of print on 8 November 2010; DOI:10.1128/AAC.01064-10]
Elvitegravir(GS-9137) purchased from Selleck Chemicals.
PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
V Serra, M Scaltriti, L Prudkin, PJA Eichhorn, YH Ibrahim, S Chandarlapaty, et al.
[Oncogene 2011.]
Erlotinib Hydrochloride purchased from Selleck Chemicals.
Dual specificity phosphatase 6(DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK-signaling in lung cancer cells.
Zhenfeng Zhang, Susumu Kobayashi, Alain C. Borczuk, Rom S.Leidner, Thomas LaFramboise, et al.
[Carcinogenesis Advance Access.January 22,2010.]
Erlotinib Hydrochloride purchased from Selleck Chemicals.
Mechanisms of myogenic tone of coronary arteriole:Role of down stream signaling 2 of the EGFR tyrosine kinase.
Ali H. Amin, Zakaria Y. Abd Elmageed, Megan Partyka, Khalid Matrougui.
[YMVRE-03058; No. of pages: 8; 4C; DOI:10.1016/j.mvr.2010.11.001]
Erlotinib Hydrochloride purchased from Selleck Chemicals.
Secretory phospholipase A2-IIa is involved in prostate cancer progression and may potentially serve as a biomarker for prostate cancer.
Zhongyun Dong, Yin Liu, Kieran F.Scott, Linda Levin, Krishnanath Gaitonde, R.Bruce Bracken, et al.
[Carcinogenesis 31(11):1948-1955, 2010; DOI:10.1093/carcin/bgq188]
Erlotinib Hydrochloride | Gefitinib | Lapatinib Ditosylate | CI-1033 | Bortezomib purchased from Selleck Chemicals.
Pharmacodynamic Characterizationof the Efficacy Signals Due to Selective BRAF Inhibition with PLX4032 in Malignant Melanoma.
William D. Tap, Ke-Wei Gong, Judy Dering, Yiou Tseng, Charles Ginther, Giovanni Pauletti, John A. Glaspy, et al.
[Neoplasia. August 2010; DOI:10.1593/neo.10414]
Everolimus(RAD001) purchased from Selleck Chemicals.
Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling.
S Kitajima, T Miki, et al.
[Oncogene.2010 October; DOI:10.1038/onc.2010.448]
Gefitinib(Iressa) purchased from Selleck Chemicals.
The Mechanical Stress Activated Serum-, Glucocorticoid-Regulated Kinase 1 Contributes to Neointima Formation in Vein Grafts.
Jizhong Cheng, Ying Wang, Yewei Ma, Bonita Tak-yee Chan, et al.
[Circulation Research 2010. DOI:10.1161/CIRCRESAHA.110.222588]
KU-0063794 purchased from Selleck Chemicals.
Peroxiredoxin ii restrains dna damage-induced death in cancer Cells by positively regulating jnk-dependent dna repair.
Kyung Wha Lee, Doo Jae Lee, Joo Young Lee, Dong Hoon Kang, Jongbum Kwon and Sang Won Kang.
[JBC 2010. DOI:10.1074/jbc.M110.179416]
KU-55933 purchased from Selleck Chemicals.
An inhibitor of ADAMs (a disintegrin and metalloprotease) overcomes HER3-mediated resistance to trastuzumab and lapatinib.
P. Scherle, X. Liu, Q. Wang, G. Yang, J. Li, C. Marando, M. Covington, W. Yao, R. Newton, S. Friedman.
[Incyte Corporation, Wilmington, Delaware, USA]
Lapatinib Ditosylate purchased from Selleck Chemicals.
Induction of TAp63 by histone deacetylase inhibitors.
Berna S. Sayana, Ai Li Yang, Franco Conforti,Sergio Bernardini, Paola Tucci, Mariuca Vasa-Nicotera,Richard A. Knight and Gerry Melino.
[Biochemical and Biophysical Research Communications.January 22 2010.(P1748-1751); DOI:10.1016/j.bbrc.2009.12.147]
LBH-589(Panobinostat) purchased from Selleck Chemicals was used.
AT9283, a small molecule multi-targeted kinase inhibitor with potent activity against aurora kinase and STAT3 in combination with Lenalidomide results in synergistic anti-myeloma activity.
L. Santo, T. Hideshima, D. Cirstea, M. Bandi, E.A. Nelson, H. Ikeda, S. Vallet, S. Pozzi, K. Patel, G. Gorgun, et al.
Lenalidomide purchased from Selleck Chemicals was used.
Glutamate Agonist LY404,039 for Treating Schizophrenia Has Affinity for the Dopamine D2High Receptor.
Philip Seeman and Hong-Chang Guan.
[Synapse 63:935–939, 2009; DOI:10.1002/syn.20704]
LY404039 purchased from Selleck Chemicals.
Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells.
Hui-Fang Li, Jung-Sik Kim and Todd Waldman.
[Radiation Oncology 2009.]
MK-2206 purchased from Selleck Chemicals.
The Anandamide effect on NO/cGMP pathway in human platelets.
Maria Grazia Signorello, Enrica Giacobbe, Mario Passalacqua and Giuliana Leoncini.
[Journal of Cellular Biochemistry; DOI:10.1002/jcb.23008.]
MK-2206 purchased from Selleck Chemicals.
Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237.
Dominic A. Sloane, Michael Z. Trikic, Matthew L. H. Chu, Maria B. A. C. Lamers, Clive S. Mason et al.
[ACS Chem Biol 2010; DOI:10.1021/cb100053q]
MLN8237 purchased from Selleck Chemicals.
Emerging drugs for high-grade osteosarcoma.
Claudia Maria Hattinger, Michela Pasello, Stefano Ferrari, Piero Picci and Massimo Serra
[Informa Healthcare; DOI:10.1517/14728214.2010.505603]
MLN8237 purchased from Selleck Chemicals.
Uncovering new substrates for Aurora A kinase.
Teresa Sardon, Roland A. Pache, Amelie Stein, Henrik Molina, Isabelle Vernos and Patrick Aloy
[JEMBO reports (2010); DOI:10.1038/embor.2010.171]
MLN8237 purchased from Selleck Chemicals.
Histone Deacetylase Inhibitors Downregulate Checkpoint Kinase 1 Expression to Induce Cell Death in Non-Small Cell Lung Cancer Cells
William Brazelle, Jenny M. Kreahling, Jennifer Gemmer, Yihong Ma, W. Douglas Cress, Eric Haura,Soner Altiok.
[PLoS ONE 2010; DOI:10.1371/journal.pone.0014335]
MS-275(Entinostat) | AZD7762 purchased from Selleck Chemicals.
Strategy for identification and detection of multiple oxidative modifications within proteins applied on persulfate-oxidized hemoglobin and human serum albumin
Harriet Mo¨ rtstedt, Marina C. Jeppsson, Giovanni Ferrari, Bo A.G. Jo¨ nsson, Monica H. Ka˚redal and Christian H. Lindh.
[Rapid Commun. Mass Spectrom 2011; DOI:10.1002/rcm.4867]
FFESFGDLSTPDAVMoxGNPK(Hb) and AVMoxDDFAAFVEK(HSA) purchased from Selleck Chemicals.
A Feedback Loop between Androgen Receptor and ERK Signaling in Estrogen Receptor–Negative Breast Cancer
Kee Ming Chia, Ji Liu, Glenn D. Francis and Ali Naderi
[Neoplasia 2011; DOI:10.1593/neo.101324]
PD0325901 | CI-1040(PD184352) purchased from Selleck Chemicals.
BRAF Gene Amplification Can Promote Acquired Resistance to MEK Inhibitors in Cancer Cells Harboring the BRAF V600E Mutation.
Ryan B. Corcoran, Dora Dias-Santagata, Kristin Bergethon, A. John Iafrate, Jeffrey Settleman and Jeffrey A. Engelman
[Science Signaling 3 (149), ra84; DOI:10.1126/scisignal.2001148]
PD0325901 | CI-1040(PD184352) | U0126-EtOH | PLX4720 purchased from Selleck Chemicals.
RDEA119/BAY 869766:A Potent, Selective, Allosteric Inhibitor of MEK 1/2 for the Treatment of Cancer.
Cory Iverson, Gary Larson, Chon Lai, Li-Tain Yeh, Claudia Dadson,Paul Weingarden, Todd Appleby,Todd Vo,Andreas Maderna, et al.
[Cancer Research.September 1 2009.(P6839~6847)]
PD0325901 purchased from Selleck Chemicals.
Inhibition of poxvirus spreading by the anti-tumor drug Gefitinib(IressaTM).
Stefan Langhammer, Robert Koban, Constanze Yue, Heinz Ellerbrok
[AVR-2735; No.of Pages7; DOI: 10.1016/j.antiviral.2010.11.006]
PD153035 hydrochloride | Vandetanib | Gefitinib(Iressa) purchased from Selleck Chemicals.
Inhibitors of MAPK Pathway ERK1/2 or p38 prevent the IL-1β-induced upregulation of SRP72 Autoantigen in Jurkat Cells.
Victor E. Arana-Argaez, Vidal Delgado-Rizo Oscar E. Pizano-Martinez, Erika Aurora Martinez-Garcia et al.
[JBC.October 1, 2010, 285 (40); DOI:10.1074/jbc.M110.121087]
PD98059 | SB 203580 | SB 201090 purchased from Selleck Chemicals.
Antitumoral alkylphospholipids induce cholesterol efflux from the plasma membrane in HepG2 cells.
Pablo Ríos-Marco, José M. Jiménez-López, Carmen Marco, Josefa L. Segovia and María P. Carrasco.
[JPET Fast Forward. 2010; DOI:10.1124/jpet.110.172890]
Perifosine purchased from Selleck Chemicals.
Disruption of cellular cholesterol transport and homeostasis as a novel mechanism of action of membrane-targeted alkylphospholipid analogues.
María P Carrasco, José M Jiménez-López, Pablo Ríos-Marco, Josefa L Segovia and Carmen Marco.
[British Journal of Pharmacology 2010; DOI:10.1111/j.1476-5381.2010.00689.x]
Perifosine purchased from Selleck Chemicals.
Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation.
Hong-rong Fei, Geng Chen, Jian-mei Wang and Feng-ze Wang.
[Cytotechnology.September 15, 2010; DOI: 10.1007/s10616-010-9299-4]
Perifosine purchased from Selleck Chemicals.
Insulin-Like Growth Factor I Suppresses Bone Morphogenetic Protein Signaling in Prostate Cancer Cells by Activating mTOR Signaling.
Reema S. Wahdan-Alaswad, Kyung Song, Tracy L. Krebs, Dorjee T.N. Shola,Jose A. Gomez, et al.
[Cancer Res; 70(22) November 15, 2010; DOI:10.1158/0008-5472.CAN-10-1119]
Perifosine purchased from Selleck Chemicals.
Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell-lymphotoxindependent pathway.
Varsha Kumar, Elke Scandella, Renzo Danuser,Lucas Onder,Maximilian Nitschké,Yoshinori Fukui,Cornelia Halin, Burkhard Ludewig and Jens V. Stein1.
[Blood.February 25 2010.10.1182/blood-2009-10-250118]
Sunitinib purchased from Selleck Chemicals.
Differences in Wound Healing in Mice with Deficiency of IL-6 versus IL-6 Receptor
Molly M. McFarland-Mancini,Holly M. Funk, Andrew M. Paluch,Mingfu Zhou,Premkumar Vummidi Giridhar,Carol A. Mercer,Sara C. Kozma and Angela F. Drew.
[J. Immunol. 2010;184;7219-7228; originally published online May 10,2010; DOI:10.4049/jimmunol.0901929]
U0126 purchased from Selleck Chemicals.
Activity of the Aurora Kinase Inhibitor VX-680 against
Bcr/Abl-Positive Acute Lymphoblastic Leukemias
Fei Fei, Sonia Stoddart, John Groffen and Nora Heisterkamp.
[Molecular Cancer Therapeutics. May 2010.]
VX-680 purchased from Selleck Chemicals.
A novel xenograft model of cutaneous T-cell lymphoma
Thorbjørn Krejsgaard, Katharina Kopp, Elisabeth Ralfkiaer, Ayelah E. Willumsgaard, et al.
[Experimental Dermatology. 2010; DOI:10.1111/j.1600-0625.2010.01138.x]
Vorinostat(SAHA) purchased from Selleck Chemicals.
Itch/AIP4-independent proteasomal degradation of cFLIP induced by the histone deacetylase inhibitor SAHA sensitizes breast tumour cells to TRAIL
Rosario Yerbes and Abelardo López-Rivas
[Investigational New Drugs,published online:15 November 2010; DOI: 10.1007/s10637-010-9597-x]]
Vorinostat(SAHA) purchased from Selleck Chemicals.
DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination
Zhanwen Du, Jing Song, Yong Wang, Yiqing Zhao, Kishore Guda, Shuming Yang, et al.
[Science Signaling 3 (146), ra80; DOI:10.1126/scisignal.2001462]
Vorinostat(SAHA) | MS-275(Entinostat) | LBH-589(Panobinostat) purchased from Selleck Chemicals.
Sunitinib deregulates tumor adaptation to hypoxia by inhibiting HIF-1a synthesis in HT-29 colon cancer cells
Hyun-Woo Shin, Chung-Hyun Cho, Tae-You Kim, Jong-Wan Park
[Biochemical and Biophysical Research Communications 398 (2010); DOI:10.1016/j.bbrc.2010.06.060]
Sunitinib Malate(Sutent) purchased from Selleck Chemicals.
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