p97

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No. Information Product Use Citations Product Validations
S7285

NMS-873

NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM.

S7199

DBeQ

DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.

S4921

MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)

MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.

Catalog No. Information Product Use Citations Product Validations
S7285

NMS-873

NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM.

S7199

DBeQ

DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.

S4921

MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)

MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.