p97

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S7285 NMS-873 <1 mg/mL 100 mg/mL <1 mg/mL
S7199 DBeQ <1 mg/mL 68 mg/mL 5 mg/mL
S4921 MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN) <1 mg/mL 39 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations
S7285

NMS-873

NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).

S7199

DBeQ

DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.

S4921

MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)

MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.