Product Categories

New Products

Product Categories
PI3K/Akt/mTOR
JAK/STAT
Cell Cycle
DNA Damage
TGF-beta/smad
GPCR & G Protein
RTK
Epigenetics
NF-κB
Metabolism
Proteases
Microbiology
Apoptosis
MAPK
Angiogenesis
Stem Cell & Wnt
Neuronal Signaling
Others

PI3K/Akt/mTOR

water-soluble

Cat.No. Product Name Information
S7063 LY2090314 LY2090314 is a potent GSK-3 inhibitor for GSK-3α and GSK-3β with IC50 of 1.5 nM and 0.9 nM, respectively.
S7064 FMK FMK is a potent, highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1and RSK2.
S7028 IPI-145 (INK1197) IPI-145 (INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM.
S2163 PF-4708671 PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki of 20 nM and IC50 of 160 nM.
S8019 AZD5363 AZD5363 is a potent Akt inhibitor for Akt1, Akt2 and Akt3 with IC50 of 3 nM, 8 nM and 8 nM, respectively.
S8002 GSK2636771 GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor.
S3056 Miltefosine (Hexadecylphosphocholine) Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa.
S2870 TG 100713 TG 100713 is a PI3K inhibitor for PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.
S2814 BYL719 BYL719 strongly and selectively inhibits PI3Kα.
S2817 Torin 2 Torin 2 is a highly potent and selective mTOR inhibitor with IC50 of 0.25 nM, and also exhibits potent cellular activity against ATM/ATR/DNA-PK with EC50 of 28 nM, 35 nM and 118 nM, respectively.

JAK/STAT

water-soluble

Cat.No. Product Name Information
S7024 Stattic  
S8004 ZM 39923 HCl ZM39923 is an JAK inhibitor for JAK1, JAK3, EFGR and TGM2 with IC50 of 4.4 μM, 7.1 μM, 5.6 μM and 10 nM, respectively.
S8005 SMI-4a SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM.
S2867 WHI-P154 WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM and also inhibits EGFR with IC50 of 4 nM.
S2851 Baricitinib (LY3009104, INCB28050) Baricitinib is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, respectively.
S2796 WP1066 WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells .
S2789 Tofacitinib (CP-690550, Tasocitinib) CP-690550 is a novel inhibitor of JAK3 with IC50 of 1 nM.
S2902 S-Ruxolitinib S-Ruxolitinib is a JAK family inhibitor for JAK1 and JAK2 with IC50 of 3.3 nM and 2.8 nM, respectively.
S2736 TG101348 (SAR302503) TG-101348 (SAR302503) is a selective inhibitor of JAK2 with IC50 of 3 nM.
S2692 TG101209 TG101209 is a potent inhibitor of JAK2, Flt3 and RET with IC50 of 6 nM, 25 nM and 17 nM, respectively.

Cell Cycle

water-soluble

Cat.No. Product Name Information
S4910 ABT-348 (Ilorasertib) ABT-348 is a novel ATP-competitive inhibitor of Aurora B, Aurora C and Aurora A with IC50 of 7 nM, 1 nM and 120 nM, respectively.
S7047 BAY 1000394 BAY 1000394 is an orally bioavailable CDK inhibitor.
S1579 PD 0332991 (Palbociclib) Isethionate PD 0332991 (Palbociclib) Isethionate is the isethionate of PD 0332991, a highly specific inhibitor of CDK4 and CDK6 with IC50 of 11 nM and 16 nM, respectively.
S8031 NSC 23766 NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs).
S2768 Dinaciclib (SCH727965) Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively.
S2014 BMS-265246 BMS265246 is a potent and selective CDK inhibitor for CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 nM and 9 nM, respectively.
S2770 MK-5108 (VX-689) MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM.
S1239 TAK-960 TAK-960 is a novel, potent and selective Plk1 inhibitor with IC50 of 8 nM.
S2744 CCT137690 CCT137690 is a highly selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 15 nM, 25 nM and 19 nM, respectively.
S2751 Milciclib (PHA-848125) PHA-848125 is a potent, ATP-competitive cyclin A/CDK2 inhibitor with IC50 of 45 nM.

DNA Damage

water-soluble

Cat.No. Product Name Information
S7048 BMN 673 BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM.
S4908 SN-38 SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I.
S8038 UPF 1069 UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM.
S8007 VE-821 VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki and IC50 of 13 nM and 26 nM, respectively.
S2886 PJ34 PJ-34 is a potent PARP inhibitor with EC50 of 20 nM.
S2871 T0070907 T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM.
S2798 GW6471 GW6471 is an inhibitor of PPARα with IC50 of 0.24 μM.
S1270 CCT239065 CCT239065 is a novel and selective BRAFV600E and LCK inhibitor with IC50 of 13 nM and 6 nM, respectively.
S2075 Rosiglitazone HCl Rosiglitazone is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
S2029 Uridine Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.

TGF-beta/smad

water-soluble

Cat.No. Product Name Information
S2791 Sotrastaurin (AEB071) Sotrastaurin (AEB071) is a potent selective pan-PKC inhibitor and highly inhibits PKCθ with Ki of 0.22 nM.
S2186 SB-505124 SB505124 is a selective inhibitor of ALK4 and ALK5 with IC50 of 129 nM and 47 nM, respectively.
S2704 LY2109761 LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively.
S2750 GW788388 GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM.
S2911 Go 6983 Go 6983 is a pan PKC inhibitor against PKCα, PKCβ, PKCγ, PKCδ, PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.
S2907 Pirfenidone Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells.
S2805 LY364947 LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM.
S2618 LDN193189 LDN193189 is a selective inhibitor of ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively.
S2230 LY2157299 LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM.
S2248 CX-4945 (Silmitasertib) CX-4945 is a potent and selective inhibitor of CK2α and CK2α' with IC50 of 1 nM.

GPCR & G Protein

water-soluble

Cat.No. Product Name Information
S8022 Empagliflozin (BI10773) Empagliflozin (BI-10773) is a potent and selective SGLT2 inhibitor with IC50 of 3.1 nM.
S8030 Plerixafor (AMD3100) Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
S8012 Otenabant (CP-945598) HCl CP-945598 HCl is a potent and selective cannabinoid type 1 receptor antagonist with Ki of 0.7 nM.
S3051 Bosentan Hydrate Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively.
S3021 Rimonabant (SR141716) Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane.
S2778 GW842166X GW842166X is a potent and highly selective agonist of CB2 receptor.
S3013 Plerixafor 8HCl (AMD3100 8HCl) Plerixafor 8HCl (DB06809, Mozobil, AMD3100) is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
S2760 Canagliflozin Canagliflozin is a highly potent and selective SGLT2 inhibitor for CHO-hSGLT2, CHO-rSGLT2 and CHO-mSGLT2 with IC50 of 4.4 nM, 3.7 nM and 2 nM, respectively.
S2593 Tolvaptan (OPC-41061) Tolvaptan (OPC-41061) is a selective, competitive arginine vasopressin receptor 2 antagonist with an IC50 of 1.28µM for the inhibition of AVP-induced platelet aggregation.
S2906 Ki16198 Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively.

RTK

water-soluble

Cat.No. Product Name Information
S4911 BMS-690514  
S7005 CEP-28122 CEP-28122 is a highly potent and selective orally active ALK inhibitor with IC50 of 1.9 nM.
S7082 TAK-593 TAK-593 is a novel dual VEGFR/PDGFR inhibitor.
S7067 EMD 1214063 EMD 1214063 is a potent and selective c-Met inhibitor with IC50 of 6 nM.
S7078 Picropodophyllotoxin (Picropodophyllin, AXL1717) AXL1717 (picropodophyllin, Picropodophyllotoxin, PPP) is a non-competitive, potent, and specific inhibitor of IGF-1Rα/β with IC50 of 1 nM.
S4903 K252a K252a is a non-selective protein kinase inhibitor.
S4001 Cabozantinib malate Cabozantinib malate is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.
S8024 Tyrphostin AG 1296 (AG 1296) Tyrphostin AG 1296 (AG 1296) is an inhibitor of PDGFR, FGFR and c-Kit with IC50 of < 1 μM, 12.3 μM and 1.8 μM, respectively.
S7000 AP26113 AP26113 is a potent ALK inhibitor for ALK, FER, ROS/ROS1, FLT3 and FES/FPS with IC50 of 0.62 nM, 1.3 nM, 1.9 nM, 2.1 nM and 3.4 nM, respectively.
S8009 AG 18 (Tyrphostin 23) AG 18 inhibits EGFR with IC50 of 35 μM.

Epigenetics

water-soluble

Cat.No. Product Name Information
S8049 Tubastatin A  
S7110 (+)-JQ1  
S7062 EPZ-5676 EPZ-5676 is an S-adenosyl methionine (SAM) competitive inhibitor of DOT11L with Ki of 80 pM.
S7079 SGC 0946 SGC 0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM.
S7013 SGI-110 SGI-110 is a second generation DNA-hypomethyating agent.
S4900 Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity.
S4909 Apicidin (OSI-2040) Apicidin is a potent HDAC inhibitor with IC50 of 0.7 nM.
S1216 PFI-1 PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM.
S8006 BIX01294 BIX01294 is an inhitor of G9a histone methyltransferase with IC50 of 2.7 μM.
S8001 Rocilinostat (ACY-1215) Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM.

NF-κB

water-soluble

Cat.No. Product Name Information
S4902 QNZ (EVP4593) QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM.
S4905 PHA-408 PHA-408 is a highly selective and ATP-competitive IKK-2 inhibitor with IC50 of 40 nM.
S4906 PF-184 PF-184 is a potent and selective IKK-2 inhibitor with IC50 of 37 nM.
S4907 SC-514 SC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM.
S2913 BAY 11-7082 (BAY 11-7821) Bay 11-7082 inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM.
S2864 IMD 0354 IMD-0354 is an IKKβ inhibitor and blocks IκBα phosphorylation in NFκβ pathway.
S2863 ML130 ML130 is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM.
S2882 IKK-16 IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
S2824 TPCA-1 TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM.

Metabolism

water-soluble

Cat.No. Product Name Information
S8029 WY 14643 (Pirinixic Acid)  
S8026 GSK0660 GSK0660 is a selective PPARδ antagonist with IC50 of 155 nM.
S8046 GW7647 GW7647 is a potent and highly selective PPARα agonist with EC50 of 6 nM.
S8034 Apremilast (CC-10004) Apremilast (CC-10004) is a potent PDE4 and TNF-α inhibitor with IC50 of 74 nM and 77 nM, respectively.
S4039 Methazolamide Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
S4019 Avanafil Avanafil is a highly selective PDE5 inhibitor with IC50 of 1 nM.
S4021 Tolcapone Tolcapone is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM.
S2921 PF-4981517 PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM.
S2900 Cobicistat (GS-9350) Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.
S8020 GW0742 GW0742 is a potent and highly selective PPARβ/δ agonist, binding to hPPARδ with IC50 of 1 nM.

Proteases

water-soluble

Cat.No. Product Name Information
S7038 Epoxomicin (BU-4061T)  
S7021 GS-9256 GS-9256 is a novel phosphinic acid derived inhibitor of the HCV NS3/4A protease with IC50 of 4 nM.
S7049 Oprozomib (ONX 0912) Oprozomib (ONX 0912) selectively inhibits CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM.
S2874 Camostat Mesilate (FOY-305) Camostat is a trypsin-like protease inhibitor, inhibiting matriptase and human neutrophil elastase with IC50 of 0.5 μM and 0.2 μM, respectively.
S3031 Linagliptin (BI-1356) Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.
S3017 Aspirin (Acetylsalicylic acid) Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.
S1157 Delanzomib (CEP-18770) CEP-18770 is a potent chymotrypsin-like proteasome inhibitor with IC50 of 3.8 nM.
S2122 Deuterated Atazanivir-D3-1 Atazanivir-D3-1 is a azapeptide derivative and inhibits HIV protease.
S3010 Deuterated Atazanivir-D3-2 Atazanivir-D3-2 is a azapeptide derivative and inhibits HIV protease.
S3011 Deuterated Atazanivir-D3-3 Atazanivir-D3-3 is a azapeptide derivative and inhibits HIV protease.

Microbiology

water-soluble

Cat.No. Product Name Information
S3080 Etravirine (TMC125) Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
S2765 MK-2048 MK-2048 is an potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.
S2579 Zidovudine (Retrovir) Zidovudine (Retrovir) is a reverse transcriptase inhibitor.
S2914 Dapivirine Dapivirine is an nonnucleoside reverse transcriptase inhibitor for HIV reverse transcriptase with IC50 of 24 nM.
S3165 Abacavir sulfate Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.
S2667 S/GSK1349572 (GSK1349572) S/GSK1349572 (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM.
S1704 Emtricitabine (Emtriva) Emtricitabine (Emtriva) is a nucleoside reverse transcriptase inhibitor with an IC50 of 27.7 μM.
S1742 Nevirapine(Viramune) Nevirapine(Viramune) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
S1719 Zalcitabine Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).
S1706 Lamivudine (Epivir) Lamivudine(Epivir) is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM.

Apoptosis

water-soluble

Cat.No. Product Name Information
S7023 Z-VAD-FMK  
S8048 ABT-199 ABT-199 is a Bcl-2-selective inhibitor with Ki < 0.010 nM.
S7015 Birinapant (TL32711) Birinapant (TL32711) is a SMAC mimetic and inhibitor of IAP family proteins.
S7034 BM-1074 BM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of <1 nM.
S8037 Necrostatin-1 Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
S2927 Apoptosis Activator 2 Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.
S8000 Tenovin-1 Tenovin-1 is a p53 activator and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.
S2781 RITA (NSC 652287) RITA (NSC 652287) is a DNA damaging agent with IC50 of 2 nM and 20 nM in A498 and TK-10 cells.
S2738 PAC-1 PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM.
S2754 AT-406 AT-406 is a potent IAP (inhibitor of apoptosis protein) inhibitor of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively.

MAPK

water-soluble

Cat.No. Product Name Information
S7001 PF-04880594 PF-04880594 is a RAF inhibitor for BRAF and c-RAF with IC50 of 0.19 nM and 0.39 nM, respectively.
S4901 JNK-IN-8 JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, respectively.
S2872 GW5074 GW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM.
S8015 CEP-32496 CEP-32496 is a RAF inhibitor for BRAF(V600E), BRAF(WT), c-Raf, Abl-1 and CSF-1R with IC50 of 14 nM, 36 nM, 39 nM, 3 nM and 9 nM, respectively.
S2807 Dabrafenib (GSK2118436) Dabrafenib (GSK2118436) is a potent ATP-competitive inhibitor of B-Raf, B-RafV600E and c-Raf with IC50 of 3.2 nM, 0.8 nM and 5.0 nM, respectively.
S2746 AZ628 AZ628 is a potent inhibitor for wild-type CRAF and BRAFV600E with IC50 of 29 nM and 34 nM, respectively.
S2928 TAK 715 TAK 715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM.
S2726 PH-797804 PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM.
S2720 ZM 336372 ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM.
S2673 GSK1120212 (JTP-74057) GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively.

Angiogenesis

water-soluble

Cat.No. Product Name Information
S8023 TCS 359 TCS 359 is a potent FLT3 inhibitor with IC50 of 42 nM.
S2018 ENMD-2076 L-(+)-Tartaric acid ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, a selective inhibitor of Aurora A and Aurora B with IC50 of 14 nM and 350 nM and also inhibits Flt3, Flt4 and VEGFR2 with IC50 of 1.86 nM, 15.9 nM and 58.2 nM, respectively.
S2899 GNF-2 GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, inhibiting the proliferation of the Bcr-Abl-expressing cells with IC50 of 138 nM.
S2801 AZD4547 AZD4547 is a novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3 with IC50 of of 0.2 nM, 2.5 nM, and 1.8 nM, respectively.
S3026 Piceatannol Piceatannol is a selective Syk inhibitor with IC50 of ~10 μM.
S1007 FG-4592 FG-4592 is an HIF α prolyl hydroxylase inhibitor.
S2183 BGJ398 (NVP-BGJ398) BGJ398 (NVP-BGJ398) is a potent and selective inhibitor of FGFR1, FGFR2 and FGFR3 with IC50 of 0.9 nM, 1.4 nM and 1 nM, respectively.
S1018 Dovitinib (TKI-258) Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.
S2919 IOX2 IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM.
S2013 PF 573228 PF 573228 is a inhibitor of FAK with IC50 of 4 nM.

Stem Cell & Wnt

water-soluble

Cat.No. Product Name Information
S7085 IWP-2 IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM.
S7086 IWR-1-endo IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM.
S2777 PF-5274857 PF-5274857 is a potent and selective Smoothened (Smo) antagonist with IC50 and Ki of 5.8 nM and 4.6 nM, respectively.
S2662 ICG-001 ICG-001 specifically binds to CBP with IC50 of 3 μM.
S2157 LY2940680 LY2940680 binds to the Smo receptor and potently inhibits Hh signaling.
S2151 LDE225 (NVP-LDE225, Erismodegib) LDE225 (NVP-LDE225) is a smoothened antagonist with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
S1180 XAV-939 XAV-939 is a selective Wnt β-catenin-mediated transcription inhibitor for TNKS1 and TNKS2 with IC50 of 11 nM and 4 nM, respectively.
S1146 Cyclopamine Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM.
S1082 Vismodegib (GDC-0449) GDC-0449 (Vismodegib, HhAntag691) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM.

Neuronal Signaling

water-soluble

Cat.No. Product Name Information
S4109 Lorcaserin HCl  
S4112 Desvenlafaxine Succinate  
S4113 Desvenlafaxine  
S4051 Nabumetone Nabumetone is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX.
S4053 Sertraline HCl Sertraline HCl is a 5-HT antagonist with Ki of 13 nM.
S4043 Tetrahydrozoline HCl Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity.
S4034 Diphemanil Methylsulfate Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).
S4024 Homatropine Methylbromide Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
S4025 Homatropine Bromide Homatropine Bromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
S4026 Hydroxyzine 2HCl Hydroxyzine is a histamine H1-receptor antagonist, inhibits binding of [3H]pyrilamine/[3H]desloratadine to human histamine H1 receptor with IC50 of 10 nM/19 nM.

Others

water-soluble

Cat.No. Product Name Information
S4110 Estradiol Benzoate  
S4111 Dicloxacillin Sodium  
S7070 GSK J4 HCl  
S8028 Tariquidar  
S7046 Brefeldin A Brefeldin A is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells.
S7059 VX-661 VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface.
S4056 Retapamulin Retapamulin is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM.
S4057 Methyclothiazide Methyclothiazide (MCTZ) is a thiazide diuretic, inhibits the contractile response induced by norepinephrine which is mediated by an endothelium-dependent mechanism involving endothelium-dependent relaxing factor (EDRF)/nitric oxide (NO) release.
S4058 Ropivacaine HCl Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.
S4059 Sodium Nitroprusside Sodium Nitroprusside is a potent vasodilator working through releasing NO spontaneously in blood.