New ALK Inhibitors

Catalog No.	Product Name	Information
E6803	TRI-611	TRI‑611 is a potent, brain‑penetrant molecular glue degrader of ALK fusion proteins that recruits CRBN to a distal degron, promoting polyubiquitination and degradation of wild‑type and TKI‑refractory ALK, and inducing tumor regressions in ALK‑positive NSCLC models.
E6661	Ontunisertib	Ontunisertib (AGMB-129) is an oral, GI-restricted small molecule inhibitor of ALK5 (TGFβR1), exhibiting the potential to treat fibrostenosing Crohn’s disease (FSCD). It potently blocks pro-fibrotic TGFβ signaling locally in the GI tract via high first-pass metabolism.
S9959	Zotizalkib	Zotizalkib(TPX-0131) is a compact macrocyclic potent CNS-penetrant, next-generation inhibitor of wild-type ALK and ALK-resistant mutations with an IC50 of 1.4 nM for wild-type ALK. It exhibits antitumor efficacy and can be used in non–small cell lung cancer research.
≡ All ALK Inhibitors