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|Solubility (25°C) *||In vitro||DMSO||50 mg/mL warmed (98.68 mM)|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Description||PI-3065 is a selective p110δ inhibitor with IC50 of 15 nM, >70-fold selectivity over other PI3K family members.|
|In vitro||PI-3065 shows no inhibition on the growth of 4T1 cells, which do not expressing detectable levels of p110δ. |
|In vivo||In mouse model, PI-3065 (75 mg/kg, p.o.) also suppresses 4T1 tumor growth and metastasis via inactivation of p110δ. In the LSL.KrasG12D/+; p53R172H/+; PdxCretg/+ (or KPC) model of pancreatic ductal adenocarcinoma, PI-3065 prolongs survival and reduces the incidence of macroscopic metastases and other disease-associated pathologies. |
|Cell lines||4T1 cells|
|Incubation Time||48 hours|
Proliferation of 4T1 cells is assayed following a 4-h treatment with the indicated p110δ inhibitors, then washing and MTS staining are carried out after 48 h culture.
|Animal Models||Female WT BALB/c mice bearing 4T1 tumors|
|Formulation||0.5% methylcellulose with 0.2% Tween 80|
|Dosages||75 mg/kg, once daily|
PLEASE KEEP THE PRODUCT UNDER -20°C FOR LONG-TERM STORAGE.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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