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|Solubility (25°C) *||In vitro||DMSO||63 mg/mL (198.52 mM)|
|Ethanol||5 mg/mL warmed (15.75 mM)|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Chemical Name||2-[([1,1'-biphenyl]-4-ylamino)carbonyl]-benzoic acid|
|Description||Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.|
|In vitro||Kartogenin induces chondrocyte differentiation from hMSCs by enhancing the nuclear localization of CBFβ, and protects articular chondrocytes.  Kartogenin promotes the type-I collagen synthesis of dermal fibroblasts via activation of the smad4/smad5 pathway without obvious cytotoxicity on fibroblasts’ viability, morphology and survival. |
|In vivo||Kartogenin promotes cartilage repair in collagenase VII (10 μM)– and surgery (100 μM)-induced OA models in mice.  Kartogenin (100 nM) also stimulats collagen synthesis in the mouse dermis.  In addition, Kartogenin stimulates mouse limb skeletal growth and synovial joint development. |
|Incubation Time||48 hours|
|Method||For the cell viability assay, fibroblasts are seeded on six-well plates, followed by Kartogenin or DMSO treatment. According to the manufacturer’s instructions, cell viability and viability are assessed by AlamarBlue assay.|
|Animal Models||Collagenase VII-induced OA mouse model and Surgery-induced OA mouse model|
|Dosages||10 μM or 100 μM|
Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance. [Duffy DJ, et al. Genome Med, 2017, 10.1186/s13073-017-0407-3]PubMed: 28187790
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