Kartogenin

Print

Technical Data

Molecular Weight 317.34 Storage powder
Formula

C20H15NO3

-- -- --
CAS No. 4727-31-5 Synonyms N/A
Solubility (25°C) * In vitro DMSO 63 mg/mL (198.52 mM)
Ethanol 5 mg/mL warmed (15.75 mM)
Water Insoluble
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 2-[([1,1'-biphenyl]-4-ylamino)carbonyl]-benzoic acid

Biological Activity

Description Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
Targets
Smad4 [1]
()
Smad5 [1]
()
In vitro Kartogenin induces chondrocyte differentiation from hMSCs by enhancing the nuclear localization of CBFβ, and protects articular chondrocytes. [1] Kartogenin promotes the type-I collagen synthesis of dermal fibroblasts via activation of the smad4/smad5 pathway without obvious cytotoxicity on fibroblasts’ viability, morphology and survival. [2]
In vivo Kartogenin promotes cartilage repair in collagenase VII (10 μM)– and surgery (100 μM)-induced OA models in mice. [1] Kartogenin (100 nM) also stimulats collagen synthesis in the mouse dermis. [2] In addition, Kartogenin stimulates mouse limb skeletal growth and synovial joint development. [3]
Features  

Protocol (Only for Reference)

Cell Assay: [2]

Cell lines Fibroblasts
Concentrations ~1 μM
Incubation Time 48 hours
Method For the cell viability assay, fibroblasts are seeded on six-well plates, followed by Kartogenin or DMSO treatment. According to the manufacturer’s instructions, cell viability and viability are assessed by AlamarBlue assay.

Animal Study: [1]

Animal Models Collagenase VII-induced OA mouse model and Surgery-induced OA mouse model
Formulation Saline
Dosages 10 μM or 100 μM
Administration Intra-articular injection
 

References

Kartogenin has been referenced in 1 publications.

PLEASE KEEP THE PRODUCT UNDER -20°C FOR LONG-TERM STORAGE.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.

Chemical Structure

Return Policy

Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 365 days of its original purchase date.

Toll Free:
(877) 796-6397
-- USA and Canada only --
Fax:
+1-713-796-9816
Orders:
+1-832-582-8158
sales@selleckchem.com
Tech Support:
+1-832-582-8158 Ext:3
tech@selleckchem.com
(Please provide your Order Number in the email. We strive to reply to all email inquiries within one business day.)
Website:
www.selleckchem.com