Amoxicillin Sodium

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Technical Data

Molecular Weight (MW) 387.39
Formula

C16H18N3O5S.Na

CAS No. 34642-77-8
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms Amoxycillin
Solubility (25°C) * In vitro DMSO 78 mg/mL (201.34 mM)
Water 78 mg/mL (201.34 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name (2S,​5R,​6R)​-6-​[[(2R)​-​2-​amino-​2-​(4-​hydroxyphenyl)​acetyl]​amino]​-​3,​3-​dimethyl-​7-​oxo-​4-​thia-​1-​azabicyclo[3.2.0]​heptane-​2-​carboxylic acid, sodium salt (1:1)​

Biological Activity

Description

Amoxicillin sodium (Amox) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic. Amoxicillin sodium (Amox) is used to treat bacterial infections caused by susceptible microorganisms. Amoxicillin sodium (Amox) is usually the drug of choice within the class because it is better absorbed, following oral administration, than other β-lactam antibiotics. Amoxicillin sodium (Amox) is susceptible to degradation by β-lactamase-producing bacteria, which are resistant to a broad spectrum of β-lactam antibiotics, such as penicillin. For this reason, it is often combined with clavulanic acid. Amoxicillin sodium (Amox) acts by inhibiting the synthesis of bacterial cell walls. Amoxicillin sodium (Amox) inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell walls of both Gram-positive and Gram-negative bacteria. [1]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

PLEASE KEEP THE PRODUCT UNDER -20°C FOR LONG-TERM STORAGE.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE

Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Short-term storage of many products are stable in the short-term at temperatures that differ from that required for long-term storage.
We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, follow the storage recommendations on the product data sheet.

Amoxicillin Sodium Chemical Structure

Return Policy

Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 365 days of its original purchase date.