The kinesins constitute a large family of microtubule-dependent motor proteins that are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. KIF7 (kinesin family member 7) is a 1,343 amino acid protein expressed in embryonic stem cells, melanotic melanoma and Jurkat T-cells. KIF7 is a member of the KIF27 subfamily of the kinesin-like protein family and contains one kinesin-motor domain. It is suggested that KIF7 may participate in the Hedgehog (Hh) signaling pathway by regulating the proteolysis and stability of GLI transcription factors. Hedgehog (Hh) signaling plays a critical role in embryonic development.
A synthetic peptide conjugated to KLH.
KIF7 Mouse mAb detects endogenous levels of KIF7 protein.
Supplied in PBS,1 mg/ml BSA, 50% glycerol and less than 0.02% sodium azide, PH 7.4. Store at -20°C. Stable for one year
Use an anti-mouse secondary antibody to detect the antibody.
|Not yet tested in other applications|
Western blot analysis of Hela cell lysate with KIF7 mouse mAb (4A5) diluted at 1:1000. Predicted molecular weight: 151 kDa.
KIF7 mouse mAb (4A5) at 1:200 dilution staining KIF7 by immunohistochemistry on paraffin-embedded human breast cancer tissue.