APC

Inhibition of CDC20 potentiates anti-tumor immunity through facilitating GSDME-mediated pyroptosis in prostate cancer

41 views | Nov 10 2023

The study reveals that CDC20 negatively regulates pyroptosis by targeting GSDME for ubiquitin-mediated proteolysis in prostate cancer, and its inhibition enhances anti-tumor immunity and synergizes with anti-PD1-based immunotherapy, offering novel therapeutic avenues for this cancer type. [Read the Full Post]

Here we assess the in vitro and in vivo anti MM activity of MLN8237

2827 views | Feb 26 2014

MLN8237 shows >200-fold higher selectivity for Aurora A than the structurally related Aurora B with an IC50 of 396.5 nM, and does not have any significant activity against 205 other kinases. [Read the Full Post]

Peters, J. M. (2006). "The anaphase promoting complex/cyclosome: a machine designed to destroy." Nat Rev Mol Cell Biol 7(9): 644-656.

3723 views | May 8 2011

This article which was published in Nature review molecular cell biology reviews not only APC/C subunits and substrates, but the functions, regulation, and inhibition of APC during the 10 years since APC was discovered. [Read the Full Post]