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Prostate Specific Antigen Antibody (5A11E9,5A11E2)

Mouse Monoclonal Antibody
Size Price Quantity
100μl USD 250
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Product Information
Prostate Specific Antigen Antibody (5A11E9,5A11E2) Antibody Datasheet
Clonality: Mouse Monoclonal Antibody
Isotype: Mouse IgG1
Clone Number: 5A11E9,5A11E2
Reactivity: Human
Molecular Weight:
Swiss-Prot:

P07288
Sensitivity: Prostate Specific Antigen Mouse mAb detects endogenous levels of Prostate Specific Antigen protein.
Immunogen:

Purified recombinant fragment of human Prostate Specific Antigen (aa26-251) expressed in E. coli.
Storage: Supplied in PBS, 0.005% sodium azide, PH 7.4. Store at -20°C. Stable for one year from the date of shipment.
Synonyms: KLK3 antibody; APS antibody; KLK2A1 antibody; PSA antibody; hK3 antibody; P-30 antigen antibody; gamma-seminoprotein antibody; kallikrein-3 antibody; prostate-specific antigen antibody; semenogelase antibody; seminin antibody; kallikrein-re

Tested Applications

Applications Recommended Dilutions Protocols
Western blot 1:500 - 1:2000
Immunohistochemistry 1:200 - 1:1000
Flow cytometry 1:200 - 1:400
Enzyme-linked Immunosorbent assay 1:10000

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Application Data

  • Western blot analysis using Prostate Specific Antigen mouse mAb against truncated Prostate Specific Antigen recombinant protein.
  • Immunohistochemical analysis of paraffin-embedded human prostate carcinoma tissues, showing cytoplasmic localization using Prostate Specific Antigen mouse mAb with DAB staining.
  • Immunohistochemical analysis of paraffin-embedded human prostate tissues using Prostate Specific Antigen mouse mAb with DAB staining.
  • Flow cytometric analysis of PC-3 cells using Prostate Specific Antigen mouse mAb (right) and negative control (left).

Background

Kallikrein 3, commonly known as prostate specific antigen (PSA), is a serine protease of the human tissue Kallikrein gene family [1]. PSA is synthesized in the ductal and acinar epithelium of the prostate gland and secreted into the seminal plasma in high concentrations (0.5 ­ 2 g/L) [2]. A small portion of PSA “leaks” into the systemic circulation, the levels of which increase significantly (30­fold) from prostate cancer tissue than normal prostate tissue [3]. PSA has become a well-established tumor marker that aids the diagnosis, staging, and follow up of prostate cancer. The deduced amino acid sequence of human PSA consists of a signal peptide, a short pro region and a mature/active enzyme. The pro­enzyme is activated, possibly by active Kallikreins 2, 4 or 15 in vivo [4]. rhPSA is activated by thermolysin, a zinc protease. The active PSA cleaves several tyrosyl peptide bonds in semenogelins I and II, which are the major gel­forming proteins produced by the seminal vesicles [5]. Several inhibitors including serpin A3/α1­antichymotrypsin (ACT) and α2­macroglobulin are known to form complexes with PSA.

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