ATF4 rabbit polyclonal antibody detects endogenous levels of ATF4 protein
Immunogen:
Storage:
The ultimate concentration of our antibody is 2mg/ml and is preserved in PBS with 0.1% sodium azide, 50% glycerol.Store at -20°C. Stable for one year from the date of shipment.
Western blot analysis of extracts from mouse craniofacial and mouse gastrocnemius, using ATF4 antibody.
Immunohistochemistry of paraffin-embedded Breast cancer using ATF4 Antibody.Dilution 1:100-200.
Background
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined.Tissue specificity: Abundant expression seen in the brain.
