Spartalizumab (anti-PD-1) | PD-1/PD-L1 | Read Reviews & Product Use Citations

Spartalizumab (anti-PD-1) is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1. It binds to PD-1 with high affinity and inhibits the biological activity of PD-1, MW: 145.8 KD.

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Selleck's Spartalizumab (anti-PD-1) has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99% Protein concentration: 4.54 mg/ml Endotoxin Level: <1 EU/mg

99.0

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Biological Activity

Description

Spartalizumab (anti-PD-1) is a humanized anti-PD-1 IgG4 antibody that blocks the binding of PD-L1 and PD-L2 to PD-1. It binds to PD-1 with high affinity and inhibits the biological activity of PD-1, MW: 145.8 KD.

Features

Human IgG4

Targets

PD-1 ^[1]

In Vivo
In vivo	In phase 1/2 studies, PDR001 has a manageable safety profile and preliminary antitumor activity in advanced solid tumors^[1].

References
[1] J. Vansteenkiste, et al. Journal of Thoracic Oncology. 2017, 12(11):suppl2, S2402.

References

[1] J. Vansteenkiste, et al. Journal of Thoracic Oncology. 2017, 12(11):suppl2, S2402.

Product Details

CAS No.	1935694-88-4
Isotype	Human IgG4
Source	CHO cells
Formulation	PBS buffer, pH 7.2
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

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Frequently Asked Questions

Question 1:
How to store the antibody?

Answer:
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.