Bradykinin

Name: Bradykinin
Brand: Selleck Chemicals
SKU: E0037
Rating: 5 (1 reviews)

Catalog No.E0037 Purity: 99.95%

Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF.

Bradykinin Chemical Structure

CAS: 58-82-2

Purity & Quality Control

Batch: E003701 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] Insoluble] false Purity: 99.95%

99.95

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Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Bioactive Compound Library-Ⅱ Express-Pick Library	Click to Expand

Biological Activity

Description	Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT06109142	Not yet recruiting	Critically Ill Patients	Assistance Publique - Hôpitaux de Paris	April 1 2024	--
NCT06210698	Not yet recruiting	Angioedema\|Angioedemas Hereditary\|Urticaria\|Mastocytosis\|ACE Inhibitor-Induced Angioedema\|C1 Inhibitor Deficiency\|Systemic Mastocytoses\|Indolent Systemic Mastocytosis	Foundation For Rare Disease Research\|Institute for Asthma & Allergy\|Virant Diagnostics Inc.\|MedBio Reference Laboratories Inc.	January 15 2024	--
NCT06380699	Completed	Acute Ischemic Stroke	Changzhou Qianhong Bio-pharma Co. Ltd.	March 16 2023	Phase 1
NCT05304091	Unknown status	Bradykinin-mediated Angioedema	University Hospital Lille	August 2022	--
NCT04763577	Recruiting	Angio-Oedema Caused by Angiotensin-Converting-Enzyme Inhibitor	University Hospital Grenoble\|University Hospital Paris\|University Hospital Rouen	October 27 2021	--

References

[1] B Hornig, et al. Circulation. 1997 Mar 4;95(5):1115-8.

Chemical Information & Solubility

Molecular Weight	1060.21	Formula	C₅₀H₇₃N₁₅O₁₁
CAS No.	58-82-2	SDF	--
Smiles	NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(CC5=CC=CC=C5)C(=O)NC(CCCN=C(N)N)C(O)=O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (94.32 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble

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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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